Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 2/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.60 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.60 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | BACE1 | P56817 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7477011 | 0.91 | SLC18A3 (0.59) | QDPRKCNH2HRH3NPY5RSLC18A3 | |
| SCHEMBL19493962 | 0.89 | RAB9A (0.63) | KCNH2HRH3POLBALDH1A1NPC1 | |
| SCHEMBL1197270 | 0.89 | RAB9A (0.63) | KCNH2HRH3POLBALDH1A1NPC1 | |
| SCHEMBL13589641 | 0.86 | HRH3 (0.57) | KCNH2HRH3SLC18A3POLBALDH1A1 | |
| SCHEMBL27888979 | 0.85 | KCNH2 (0.73) | KCNH2HRH3SLC18A3POLBALDH1A1 | |
| SCHEMBL1531725 | 0.85 | KCNH2 (0.59) | KCNH2HRH3SLC18A3POLBALDH1A1 | |
| SCHEMBL7230489 | 0.84 | QDPR (0.60) | QDPRKCNH2HRH3NPY5RPOLB | |
| SCHEMBL12874043 | 0.84 | QDPR (0.64) | QDPRNPY5RSLC18A3ALDH1A1NPC1 | |
| SCHEMBL7277302 | 0.84 | QDPR (0.69) | QDPRKCNH2HRH3NPY5RPOLB | |
| Hydrogen Sulfide SCHEMBL27863722 | 0.83 | KCNH2 (0.58) | KCNH2HRH3SLC18A3POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230019032-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2023-01-19 | — | — | US | disclosed |
| EP-3184520-B1 | SALT OF MONOCYCLIC PYRIDINE DERIVATIVE AND CRYSTAL THEREOF | EISAI R&D MAN CO LTD (JP) | 2022-03-23 | — | — | EP | disclosed |
| US-11001575-B1 | Benzolactam compounds as protein kinase inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2021-05-11 | — | — | US | disclosed |
| EP-3209664-B1 | BICYCLIC HETEROARYL AMINE COMPOUNDS AS PI3K INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-06-03 | — | — | EP | disclosed |
| US-10457669-B2 | Benzolactam compounds as protein kinase inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2019-10-29 | — | — | US | disclosed |
| US-20190047990-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2019-02-14 | — | — | US | disclosed |
| US-9951047-B2 | Salt of monocyclic pyridine derivative and crystal thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-04-24 | — | — | US | disclosed |
| US-9951047-B2 | Salt of monocyclic pyridine derivative and crystal thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-04-24 | — | — | US | disclosed |
| US-9951047-B2 | Salt of monocyclic pyridine derivative and crystal thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-04-24 | — | — | US | disclosed |
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
| EP-0608858-A1 | 5-Membered heterocycles as aggregation inhibitors | Dr. Karl Thomae GmbH (DE) | 1994-08-03 | — | — | EP | disclosed |
| EP-0604800-A1 | 4- 4- 4-(carboxyalkyl)-phenyl amino carbonyl -phenyl -piperedines as aggregation inhibitors | Dr. Karl Thomae GmbH (DE) | 1994-07-06 | — | — | EP | disclosed |
| EP-0294220-B1 | Photopolymerizable composition | HITACHI CHEMICAL CO LTD (JP) | 1994-05-25 | — | — | EP | disclosed |
| EP-0592949-A2 | N-(aminocarbonyl)-piperidines/pepirazines as aggregation inhibiting agents | Dr. Karl Thomae GmbH (DE) | 1994-04-20 | — | — | EP | disclosed |
| CN-1083485-A | Benzo thia azepine and benzo oxa-azepine derivatives | PFIZER (US) | 1994-03-09 | — | — | CN | disclosed |
| EP-0291210-B1 | ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1991-11-06 | — | — | EP | disclosed |
| US-5034429-A | An unsaturated monomer, a photoinitiator and a benzene derivative for providing a cured film | HITACHI CHEMICAL CO., LTD. (JP) | 1991-07-23 | — | — | US | disclosed |
| US-4835165-A | Antiarrhythmic 4-phenylpiperidines | PFIZER INC. (US) | 1989-05-30 | — | — | US | disclosed |
| EP-0294220-A2 | Photopolymerizable composition | Hitachi Chemical Co., Ltd. (JP) | 1988-12-07 | — | — | EP | disclosed |
| US-4188396-A | ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1980-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230019032-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | MAPK1, ALK, MAP3K1 | QDPR 3252/4885KCNH2 1719/4885HRH3 719/4885 |
| US-20190047990-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | MAPK1, ALK, MAP3K1 | QDPR 3252/4885KCNH2 1719/4885HRH3 719/4885 |
| US-11001575-B1 | Benzolactam compounds as protein kinase inhibitors | MAPK1, ALK, MAP3K1 | QDPR 3158/4885KCNH2 1705/4885HRH3 729/4885 |
| US-10457669-B2 | Benzolactam compounds as protein kinase inhibitors | MAPK1, ALK, MAP3K1 | QDPR 3252/4885KCNH2 1719/4885HRH3 719/4885 |
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRD3 | QDPR 331/4885KCNH2 3447/4885HRH3 131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.