Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 2/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | DRD5 | P21918 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR1E | P28566 | 1/20 | 0.51 |
| ▸ | TSPO | P30536 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | HTR5A | P47898 | 1/20 | 0.51 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.51 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.49 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.49 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.49 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.49 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.49 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.49 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7287663 | 0.88 | QDPR (0.62) | QDPRKCNH2ADRB3ADRA2CDRD1 | |
| SCHEMBL4969354 | 0.86 | CA12 (0.48) | QDPRKCNH2HSD11B1CA12CA1 | |
| SCHEMBL1473424 | 0.84 | QDPR (0.61) | QDPRKCNH2NPY5RHSD11B1CA12 | |
| SCHEMBL7222401 | 0.83 | CA12 (0.49) | QDPRKCNH2HSD11B1CA12CA1 | |
| SCHEMBL12306056 | 0.83 | CA12 (0.46) | QDPRKCNH2HSD11B1CA12CA1 | |
| SCHEMBL1305458 | 0.83 | HDAC3 (0.55) | QDPRP2RY14PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL7277302 | 0.83 | QDPR (0.69) | QDPRKCNH2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL12874043 | 0.83 | QDPR (0.64) | QDPRDRD3MCHR1NPY5RNPC1 | |
| SCHEMBL15379923 | 0.83 | NAMPT (0.56) | KCNH2HRH3 | |
| SCHEMBL22531787 | 0.83 | HSD11B1 (0.49) | QDPRKCNH2PRKAB2PRKAG1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184520-B1 | SALT OF MONOCYCLIC PYRIDINE DERIVATIVE AND CRYSTAL THEREOF | EISAI R&D MAN CO LTD (JP) | 2022-03-23 | — | — | EP | disclosed |
| US-20220041559-A1 | BENZO-AND PYRIDO-PYRAZOLES AS PROTEIN KINASE INHIBITORS | ROTTAPHARM BIOTECH S.R.L. (IT) | 2022-02-10 | — | — | US | disclosed |
| US-9951047-B2 | Salt of monocyclic pyridine derivative and crystal thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-04-24 | — | — | US | disclosed |
| US-9951047-B2 | Salt of monocyclic pyridine derivative and crystal thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-04-24 | — | — | US | disclosed |
| US-9951047-B2 | Salt of monocyclic pyridine derivative and crystal thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-04-24 | — | — | US | disclosed |
| US-20170217935-A1 | SALT OF MONOCYCLIC PYRIDINE DERIVATIVE AND CRYSTAL THEREOF | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-08-03 | — | — | US | disclosed |
| US-20170217935-A1 | SALT OF MONOCYCLIC PYRIDINE DERIVATIVE AND CRYSTAL THEREOF | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-08-03 | — | — | US | disclosed |
| US-20170217935-A1 | SALT OF MONOCYCLIC PYRIDINE DERIVATIVE AND CRYSTAL THEREOF | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-08-03 | — | — | US | disclosed |
| EP-3184520-A1 | SALT OF MONOCYCLIC PYRIDINE DERIVATIVE AND CRYSTAL THEREOF | Eisai R&D Management Co., Ltd. (JP) | 2017-06-28 | — | — | EP | disclosed |
| EP-3184520-A1 | SALT OF MONOCYCLIC PYRIDINE DERIVATIVE AND CRYSTAL THEREOF | Eisai R&D Management Co., Ltd. (JP) | 2017-06-28 | — | — | EP | disclosed |
| US-20140235614-A1 | MONOCYCLIC PYRIDINE DERIVATIVE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-08-21 | — | — | US | disclosed |
| US-20140235614-A1 | MONOCYCLIC PYRIDINE DERIVATIVE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-08-21 | — | — | US | disclosed |
| US-20030153604-A1 | Substituted (aminoiminomethyl or aminomethyl) benzoheteroaryl compounds | AVENTIS PHARMACEUTICALS INC. | 2003-08-14 | — | — | US | disclosed |
| US-6541505-B1 | Inhibiting the activity of Factor Xa; treating a disease state associated with a physiologically detrimental excess amount of thrombin. | AVENTIS PHARMACEUTICALS INC. | 2003-04-01 | — | — | US | disclosed |
| CN-1333766-A | Substituted (aminoiminomethyl or aminomethyl) benzoheteroaryl compounds as factor xainhibitors | AVENTIS PHARM PROD INC (US) | 2002-01-30 | — | — | CN | disclosed |
| EP-1140901-A2 | SUBSTITUTED (AMINOIMINOMETHYL OR AMINOMETHYL)BENZOHETEROARYL COMPOUNDS AS FACTOR XA INHIBITORS | Aventis Pharmaceuticals Products Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039087-A2 | SUBSTITUTED (AMINOIMINOMETHYL OR AMINOMETHYL)BENZOHETEROARYL COMPOUNDS AS FACTOR XA INHIBITORS | AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) | 2000-07-06 | — | — | WO | disclosed |
| EP-0528369-B1 | Cyclic imino derivatives, pharmaceutical compositions containing them and process for their preparation | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-11-24 | — | — | EP | disclosed |
| US-5455348-A | Anticoagulants | Thomae, Karl (DE) | 1995-10-03 | — | — | US | disclosed |
| EP-0528369-A2 | Cyclic imino derivatives, pharmaceutical compositions containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-02-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217935-A1 | SALT OF MONOCYCLIC PYRIDINE DERIVATIVE AND CRYSTAL THEREOF | MPST, SLC25A1, SLC16A1 | QDPR 1081/4885KCNH2 2761/4885ADRB3 4597/4885 |
| US-20220041559-A1 | BENZO-AND PYRIDO-PYRAZOLES AS PROTEIN KINASE INHIBITORS | PDXK, MAP4K2, PLK2 | QDPR 3733/4885KCNH2 3042/4885ADRB3 2465/4885 |
| US-20140235614-A1 | MONOCYCLIC PYRIDINE DERIVATIVE | FGFR2, FGFR1, FGFR3 | QDPR 182/4885KCNH2 1041/4885ADRB3 525/4885 |
| US-20030153604-A1 | Substituted (aminoiminomethyl or aminomethyl) benzoheteroaryl compounds | SERPINC1, F2, F11 | QDPR 2464/4885KCNH2 3608/4885ADRB3 2603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.