SCHEMBL14735305

SCHEMBL14735305

C[SiH](C)OCC=Cc1cccc(Cl)c1

nearest known ligand 0.54

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
RELA Q04206 1/20 0.47
CHAT P28329 1/20 0.45
CYP1A2 P05177 2/20 0.44
CYP2C9 P11712 1/20 0.44
NFE2L2 Q16236 3/20 0.43
FBP1 P09467 1/20 0.41
GRIK1 P39086 1/20 0.41
GRIK2 Q13002 1/20 0.41
CHRM5 P08912 1/20 0.41
HPGD P15428 1/20 0.39
CYP2C19 P33261 1/20 0.39
MAOB P27338 1/20 0.39
CACNA1B Q00975 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26918235 0.79 IDO1 (0.57) RELAMAOB
SCHEMBL23443982 0.79 IDO1 (0.57) RELAMAOB
SCHEMBL5871109 0.78 NFE2L2 (0.36) NFE2L2FBP1
SCHEMBL11101680 0.78 IDO1 (0.61) RELACHATCYP1A2CYP2C9NFE2L2
SCHEMBL11101682 0.78 IDO1 (0.61) RELACHATCYP1A2CYP2C9NFE2L2
SCHEMBL7697733 0.78 RELA (0.47) RELACHATCYP1A2CYP2C9NFE2L2
SCHEMBL256033 0.75 CHAT (0.53) RELACHATCYP1A2CYP2C9NFE2L2
SCHEMBL9131505 0.75 CHAT (0.53) RELACHATCYP1A2CYP2C9NFE2L2
SCHEMBL2097935 0.75 RELA (0.45) RELACHATCYP1A2CYP2C9NFE2L2
SCHEMBL2097937 0.75 RELA (0.45) RELACHATCYP1A2CYP2C9NFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117355521-A Heteroaryl inhibitors of plasma kallikrein 武田药品工业株式会社 2024-01-05 CN disclosed
EP-2563123-A1 NOVEL BETA 3 ADRENERGIC RECEPTOR AGONISTS Merck Sharp & Dohme Corp. (US) 2013-03-06 EP disclosed