Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 2/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.44 |
| ▸ | CDK8 | P49336 | 2/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.44 |
| ▸ | MST1R | Q04912 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6246461 | 0.88 | PRKD3 (0.45) | PRKACAMAP2K2MAPK8CDK8CDK5 | |
| SCHEMBL8318622 | 0.78 | SRC (0.44) | PRKACAMAP2K2MAPK8CDK8CDK5 | |
| SCHEMBL6686751 | 0.77 | EGFR (0.52) | CLK4MAP4K4CLK2MAP4K2DYRK1A | |
| SCHEMBL3715031 | 0.77 | SRC (0.57) | PRKACAMAP2K2MAPK8CDK8CDK5 | |
| SCHEMBL6682618 | 0.75 | EGFR (0.49) | PRKACACLK4MAP4K4CLK2GSK3B | |
| SCHEMBL3711760 | 0.69 | MAPT (0.51) | PRKACAMAP2K2MAPK8CDK8CDK5 | |
| SCHEMBL13020417 | 0.69 | MAPT (0.51) | PRKACAMAP2K2MAPK8CDK8CDK5 | |
| SCHEMBL3711762 | 0.69 | MAPT (0.51) | PRKACAMAP2K2MAPK8CDK8CDK5 | |
| SCHEMBL13020071 | 0.69 | MAPT (0.48) | ALDH1A1SRCSMN1; SMN2EGFRMAPT | |
| SCHEMBL1270136 | 0.69 | CNR1 (0.44) | PRKACAMAP2K2MAPK8CDK8CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2275413-B1 | 2,4-di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | NOVARTIS AG (CH) | 2013-03-06 | — | — | EP | disclosed |