Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.49 |
| ▸ | ABL1 | P00519 | 6/20 | 0.49 |
| ▸ | CDK1 | P06493 | 4/20 | 0.49 |
| ▸ | PRKCA | P17252 | 4/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.47 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 4/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | CDC7 | O00311 | 2/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6686751 | 0.95 | EGFR (0.52) | EGFRABL1CDK1PRKCAMKNK1 | |
| SCHEMBL19507722 | 0.91 | EGFR (0.49) | EGFRABL1CDK1PRKCATTBK1 | |
| SCHEMBL6235344 | 0.90 | EGFR (0.55) | EGFRABL1CDK1PRKCATTBK1 | |
| SCHEMBL6238000 | 0.84 | ABCG2 (0.51) | EGFRABL1PRKCATTBK1TTBK2 | |
| SCHEMBL6689654 | 0.84 | FGFR1 (0.57) | EGFRABL1CDK1PRKCATTBK1 | |
| SCHEMBL6684888 | 0.82 | EGFR (0.52) | EGFRABL1CDK1PRKCATTBK1 | |
| SCHEMBL19507769 | 0.82 | EGFR (0.52) | EGFRABL1CDK1PRKCASRC | |
| SCHEMBL13861667 | 0.80 | TTBK1 (0.52) | EGFRABL1CDK1PRKCATTBK1 | |
| SCHEMBL6684639 | 0.79 | LMNA (0.57) | EGFRABL1CDK1PRKCATTBK1 | |
| SCHEMBL8116135 | 0.78 | EGFR (0.69) | EGFRABL1CDK1PRKCASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832092-B1 | ORALLY ACTIVE ADENOSINE KINASE INHIBITORS | METABASIS THERAPEUTICS INC (US) | 2004-11-17 | — | — | EP | disclosed |
| EP-0832092-A1 | ORALLY ACTIVE ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040706-A1 | ORALLY ACTIVE ADENOSINE KINASE INHIBITORS | GENSIA-SICOR (US) | 1996-12-19 | — | — | WO | disclosed |