Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14262389 | 0.77 | HTT (0.44) | TP53HTTNPSR1LMNAPTGES | |
| SCHEMBL1930172 | 0.75 | NPSR1 (0.43) | TP53HTTNPSR1LMNAPTGES | |
| SCHEMBL14735948 | 0.73 | PTGES (0.42) | TP53HTTNPSR1LMNAPTGES | |
| SCHEMBL21228644 | 0.72 | HTT (0.41) | TP53HTTNPSR1LMNAPTGES | |
| SCHEMBL14736718 | 0.72 | NPC1 (0.50) | TP53HTTNPSR1LMNAPTGES | |
| SCHEMBL17195505 | 0.71 | PTGES (0.49) | TP53HTTLMNAPTGESCYP1A2 | |
| SCHEMBL840930 | 0.69 | NPSR1 (0.41) | TP53HTTNPSR1CYP1A2SMN1; SMN2 | |
| SCHEMBL14262396 | 0.69 | NPC1 (0.53) | HTTPTGESCYP1A2SMN1; SMN2ALDH1A1 | |
| SCHEMBL1930001 | 0.67 | ALDH1A1 (0.48) | TP53HTTNPSR1LMNAPTGES | |
| SCHEMBL9915126 | 0.66 | HTT (0.47) | TP53HTTNPSR1LMNAPTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772510-B2 | PDE10 modulators | HOFFMANN-LA ROCHE INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-20130059833-A1 | PDE10 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059833-A1 | PDE10 MODULATORS | PDE10A, PDE5A, PDE2A | TP53 4640/4885HTT 3082/4885NPSR1 321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.