Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14736717 | 0.90 | LMNA (0.49) | CYP1A2SMN1; SMN2PTGESLMNAGAA | |
| SCHEMBL4142636 | 0.77 | SMN1; SMN2 (0.71) | CYP1A2SMN1; SMN2PTGESLMNAGAA | |
| SCHEMBL10642193 | 0.76 | LMNA (0.50) | CYP1A2SMN1; SMN2PTGESLMNAGAA | |
| SCHEMBL1930172 | 0.75 | NPSR1 (0.43) | NPC1CYP1A2SMN1; SMN2PTGESLMNA | |
| SCHEMBL21228674 | 0.73 | NPC1 (0.56) | NPC1CYP1A2SMN1; SMN2PTGESLMNA | |
| SCHEMBL14735948 | 0.73 | PTGES (0.42) | NPC1CYP1A2SMN1; SMN2PTGESLMNA | |
| SCHEMBL11351277 | 0.73 | LMNA (0.48) | NPC1CYP1A2SMN1; SMN2PTGESLMNA | |
| SCHEMBL14736241 | 0.72 | TP53 (0.38) | NPC1CYP1A2SMN1; SMN2PTGESLMNA | |
| SCHEMBL10666339 | 0.72 | SMN1; SMN2 (0.54) | NPC1CYP1A2SMN1; SMN2PTGESLMNA | |
| SCHEMBL10668856 | 0.72 | TP53 (0.52) | CYP1A2SMN1; SMN2PTGESLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772510-B2 | PDE10 modulators | HOFFMANN-LA ROCHE INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-20130059833-A1 | PDE10 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059833-A1 | PDE10 MODULATORS | PDE10A, PDE5A, PDE2A | NPC1 2474/4885CYP1A2 556/4885SMN1; SMN2 1133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.