Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.43 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.43 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.42 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | LATS1 | O95835 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21423578 | 0.86 | CYP3A4 (0.51) | CYP3A4NAMPTALDH1A1MEN1KMT2A | |
| SCHEMBL14736097 | 0.86 | MAPT (0.49) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL25496036 | 0.83 | CYP3A4 (0.60) | CYP3A4NAMPTALDH1A1MEN1KMT2A | |
| SCHEMBL29651385 | 0.83 | CYP3A4 (0.60) | CYP3A4NAMPTALDH1A1MEN1KMT2A | |
| SCHEMBL2821346 | 0.80 | NAMPT (0.54) | CYP3A4NAMPTALDH1A1MEN1KMT2A | |
| SCHEMBL15229186 | 0.80 | RXFP1 (0.46) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL3402444 | 0.79 | RAB9A (0.61) | CYP3A4NAMPTALDH1A1MEN1KMT2A | |
| SCHEMBL25332560 | 0.79 | L3MBTL1 (0.56) | CYP3A4NAMPTALDH1A1MEN1KMT2A | |
| SCHEMBL14736142 | 0.79 | ALDH1A1 (0.58) | CYP3A4ALDH1A1MEN1KMT2ALMNA | |
| Acetic Acid SCHEMBL28083299 | 0.76 | KMT2A (0.60) | CYP3A4NAMPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2753604-B1 | PDE10 MODULATORS | HOFFMANN LA ROCHE (CH) | 2015-08-19 | — | — | EP | disclosed |
| US-8772510-B2 | PDE10 modulators | HOFFMANN-LA ROCHE INC. (US) | 2014-07-08 | — | — | US | disclosed |
| EP-2574607-A1 | PDE10 modulators | F. Hoffmann-La Roche AG (CH) | 2013-04-03 | — | — | EP | disclosed |
| WO-2013034506-A1 | PDE10 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-14 | — | — | WO | disclosed |
| US-20130059833-A1 | PDE10 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059833-A1 | PDE10 MODULATORS | PDE10A, PDE5A, PDE2A | CYP3A4 1490/4885NAMPT 2282/4885ALDH1A1 775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.