Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 11/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9106126 | 0.86 | POLB (0.49) | PDE10ATSHR | |
| SCHEMBL1458202 | 0.86 | PDE10A (0.50) | PDE10A | |
| SCHEMBL14672263 | 0.85 | POLB (0.47) | PDE10AHPGDTSHR | |
| SCHEMBL9104762 | 0.85 | L3MBTL1 (0.51) | PDE10AKMT2ATSHRL3MBTL1KDM4E | |
| SCHEMBL11889054 | 0.84 | KMT2A (0.46) | PDE10AKMT2AL3MBTL1KDM4E | |
| SCHEMBL11888963 | 0.82 | SIGMAR1 (0.44) | PDE10AKMT2A | |
| SCHEMBL1458472 | 0.82 | HTT (0.52) | PDE10AKMT2AKDM4EALDH1A1 | |
| SCHEMBL9104373 | 0.81 | SPR (0.45) | PDE10AKMT2AL3MBTL1 | |
| SCHEMBL28006655 | 0.80 | KMT2A (0.46) | PDE10AKMT2AHPGDTSHRL3MBTL1 | |
| SCHEMBL11890121 | 0.78 | PDE10A (0.51) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103781768-B | Pde10 regulator | 霍夫曼-拉罗奇有限公司 | 2016-08-17 | — | — | CN | claimed |
| US-8772510-B2 | PDE10 modulators | HOFFMANN-LA ROCHE INC. (US) | 2014-07-08 | — | — | US | claimed |
| US-20130059833-A1 | PDE10 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | US | claimed |
| CN-103781768-B | Pde10 regulator | 霍夫曼-拉罗奇有限公司 | 2016-08-17 | — | — | CN | disclosed |
| EP-2753604-B1 | PDE10 MODULATORS | HOFFMANN LA ROCHE (CH) | 2015-08-19 | — | — | EP | disclosed |
| US-8772510-B2 | PDE10 modulators | HOFFMANN-LA ROCHE INC. (US) | 2014-07-08 | — | — | US | disclosed |
| CN-103781768-A | PDE10 modulators | HOFFMANN LA ROCHE | 2014-05-07 | — | — | CN | disclosed |
| WO-2013034506-A1 | PDE10 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-14 | — | — | WO | disclosed |
| US-20130059833-A1 | PDE10 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059833-A1 | PDE10 MODULATORS | PDE10A, PDE5A, PDE2A | PDE10A 1/4885KMT2A 2193/4885HPGD 1466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.