Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 10/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.41 |
| ▸ | RHEB | Q15382 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7711798 | 0.87 | RHEB (0.39) | CDK9RHEBSLC6A4PDK2KDM4E | |
| SCHEMBL14738748 | 0.87 | RHEB (0.39) | CDK9RHEBSLC6A4PDK2KDM4E | |
| SCHEMBL14738750 | 0.87 | RHEB (0.39) | CDK9RHEBSLC6A4PDK2KDM4E | |
| SCHEMBL14738973 | 0.87 | PDK2 (0.37) | RHEBSLC6A4PDK2KDM4EALDH1A1 | |
| SCHEMBL14739631 | 0.87 | PDK2 (0.37) | RHEBSLC6A4PDK2KDM4EALDH1A1 | |
| SCHEMBL7712729 | 0.87 | PDK2 (0.37) | RHEBSLC6A4PDK2KDM4EALDH1A1 | |
| SCHEMBL7713818 | 0.86 | RHEB (0.37) | RHEBSLC6A4PDK2KDM4EALDH1A1 | |
| SCHEMBL14739552 | 0.80 | MAPK11 (0.48) | CDK9CCNT1SLC6A4 | |
| SCHEMBL7707688 | 0.80 | HSD11B1 (0.47) | SLC6A4ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7712303 | 0.79 | MAPK11 (0.47) | HTR1ASLC6A4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130059850-A1 | AZA-INDOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2013-03-07 | — | — | US | disclosed |
| US-20130059850-A1 | AZA-INDOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2013-03-07 | — | — | US | disclosed |
| US-20130059850-A1 | AZA-INDOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2013-03-07 | — | — | US | disclosed |
| CN-102917707-A | Azaindole derivatives useful as modulators of FAAH | MERCK SHARP & DOHME | 2013-02-06 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059850-A1 | AZA-INDOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | FAAH, FAAH2, IDO1 | CDK9 977/4885CCNT1 2182/4885RHEB 2785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.