Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 3/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11010462 | 0.84 | FADS1 (0.49) | MAP2K4NOS1CHEK1GRIN2DGRIN3B | |
| SCHEMBL3593032 | 0.79 | MAP2K4 (0.50) | MAP2K4GSK3BTRPA1DAONOS1 | |
| SCHEMBL14738828 | 0.79 | MAP2K4 (0.63) | MAP2K4GSK3BTRPA1PDPK1HSP90AB1 | |
| SCHEMBL4502873 | 0.78 | PDPK1 (0.60) | MAP2K4GSK3BTRPA1PDPK1CHEK1 | |
| SCHEMBL1573990 | 0.78 | MAP2K4 (0.58) | MAP2K4PDPK1HSP90AB1DAOFGFR1 | |
| SCHEMBL4032441 | 0.77 | PDPK1 (0.75) | MAP2K4PDPK1HSP90AB1FGFR1FGFR2 | |
| SCHEMBL445902 | 0.76 | FGFR1 (0.50) | MAP2K4GSK3BPDPK1HSP90AB1FGFR1 | |
| SCHEMBL2302544 | 0.76 | PDPK1 (0.63) | MAP2K4GSK3BPDPK1HSP90AB1NOS1 | |
| SCHEMBL30016013 | 0.76 | PDPK1 (0.63) | MAP2K4GSK3BPDPK1HSP90AB1NOS1 | |
| SCHEMBL15529807 | 0.76 | GSK3B (0.48) | MAP2K4GSK3BTRPA1PDPK1DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937648-B1 | DIACYL INDAZOL DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS | SANOFI SA (FR) | 2014-11-26 | — | — | EP | disclosed |
| US-8357698-B2 | Diacyl indazole derivatives as lipase and phospholipase inhibitors | SANOFI (FR) | 2013-01-22 | — | — | US | disclosed |
| US-20100286133-A1 | Diacyl indazole derivatives as lipase and phospholipase inhibitors | SANOFI-AVENTIS (FR) | 2010-11-11 | — | — | US | disclosed |
| US-7772268-B2 | inhibitors of hormone-sensitive lipase and/or endothelial lipase; for treatment of diabetes mellitus, dyslipidemia and atherosclerotic disorders | SANOFI-AVENTIS (FR) | 2010-08-10 | — | — | US | disclosed |
| US-7521480-B2 | Aryl ureido benzoic acid derivatives and their use | NEUROSEARCH (DK) | 2009-04-21 | — | — | US | disclosed |
| US-20080287448-A1 | Diacyl indazole derivatives as lipase and phospholipase inhibitors | SANOFI-AVENTIS (FR) | 2008-11-20 | — | — | US | disclosed |
| CN-101282939-A | Diacyl indazole derivatives as lipase and phospholipase inhibitors | SANOFI AVENTIS (FR) | 2008-10-08 | — | — | CN | disclosed |
| EP-1937648-A1 | DIACYL INDAZOL DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS | sanofi-aventis (FR) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007042178-A1 | DIACYL INDAZOL DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS | SANOFI-AVENTIS (DE) | 2007-04-19 | — | — | WO | disclosed |
| US-20060069255-A1 | Novel aryl ureido benzoic acid derivatives and their use | NEUROSEARCH (DK) | 2006-03-30 | — | — | US | disclosed |
| CN-1714076-A | Novel aryl ureido benzoic acid derivatives and their use | NEUROSEARCH AS (DK) | 2005-12-28 | — | — | CN | disclosed |
| EP-1565429-A2 | ARYL UREIDO DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004046090-A2 | ARYL UREIDO DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2004-06-03 | — | — | WO | disclosed |
| US-4537966-A | 1-(Aminobenzoyl)-1H-indazol-3-ols | PENNWALT CORPORATION (US) | 1985-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287448-A1 | Diacyl indazole derivatives as lipase and phospholipase inhibitors | PNLIP, DAGLA, MGLL | MAP2K4 3435/4885GSK3B 1568/4885TRPA1 2152/4885 |
| US-20060069255-A1 | Novel aryl ureido benzoic acid derivatives and their use | GABRA5, GRIK5, GRM5 | MAP2K4 3894/4885GSK3B 4769/4885TRPA1 659/4885 |
| US-20100286133-A1 | Diacyl indazole derivatives as lipase and phospholipase inhibitors | PNLIP, DAGLA, MGLL | MAP2K4 3435/4885GSK3B 1568/4885TRPA1 2152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.