Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 3/20 | 0.61 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 3/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.46 |
| ▸ | CCND1 | P24385 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | CCND3 | P30281 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | GUSB | P08236 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032441 | 0.84 | PDPK1 (0.75) | MAP2K4PDPK1HSP90AB1FGFR1FGFR2 | |
| SCHEMBL14738828 | 0.81 | MAP2K4 (0.63) | MAP2K4PDPK1HSP90AB1FGFR1FGFR2 | |
| SCHEMBL4035759 | 0.79 | IDO1 (0.61) | MAP2K4PDPK1HSP90AB1FGFR1FGFR2 | |
| SCHEMBL4027200 | 0.78 | IDO1 (0.42) | MAP2K4PDPK1HSP90AB1FGFR1FGFR2 | |
| SCHEMBL4029772 | 0.78 | TRPA1 (0.68) | MAP2K4PDPK1HSP90AB1FGFR1FGFR2 | |
| SCHEMBL9271850 | 0.78 | MAP2K4 (0.64) | MAP2K4PDPK1HSP90AB1FGFR1FGFR2 | |
| SCHEMBL25337719 | 0.77 | FGFR1 (0.51) | MAP2K4PDPK1HSP90AB1FGFR1FGFR2 | |
| SCHEMBL29490953 | 0.77 | FGFR1 (0.51) | MAP2K4PDPK1HSP90AB1FGFR1FGFR2 | |
| SCHEMBL22801745 | 0.76 | MAP2K4 (1.00) | MAP2K4PDPK1HSP90AB1FGFR1FGFR2 | |
| SCHEMBL2955244 | 0.74 | MAP2K4 (0.55) | MAP2K4PDPK1HSP90AB1FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542976-B1 | SUBSTITUTED 4-(INDAZOL-3-YL)PHENOLS AS ESTROGEN RECEPTOR (ER) LIGANDS AND THEIR USE IN THE TREATMENT OF INFLAMMATORY DISEASES | WYETH CORP (US) | 2009-02-04 | — | — | EP | disclosed |
| US-20070225349-A1 | Substituted 4-(Indazol-3-yl)phenols | WYETH (US) | 2007-09-27 | — | — | US | disclosed |
| US-7241791-B2 | Substituted 4-(indazol-3-yl)phenols | WYETH (US) | 2007-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225349-A1 | Substituted 4-(Indazol-3-yl)phenols | INSR, TNNI3, INSRR | MAP2K4 793/4885PDPK1 2941/4885HSP90AB1 2737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.