Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4255713 | 0.87 | POLB (0.47) | POLBSMN1; SMN2RAB9AKDM4EMAPT | |
| SCHEMBL14741088 | 0.82 | MAPT (0.43) | POLBSMN1; SMN2RAB9AKDM4EMAPT | |
| SCHEMBL20613184 | 0.81 | ALDH1A1 (0.46) | POLBSMN1; SMN2RAB9AKDM4EMAPT | |
| SCHEMBL14740990 | 0.80 | CASP3 (0.58) | POLBSMN1; SMN2RAB9AKDM4EMAPT | |
| SCHEMBL8247663 | 0.80 | TAS1R3 (0.47) | POLBSMN1; SMN2RAB9AKDM4EMAPT | |
| SCHEMBL14371694 | 0.79 | GAA (0.54) | POLBSMN1; SMN2RAB9AKDM4EMAPT | |
| SCHEMBL1390803 | 0.78 | POLB (0.44) | POLBSMN1; SMN2RAB9AKDM4EMAPT | |
| SCHEMBL1390782 | 0.78 | ALDH1A1 (0.48) | POLBSMN1; SMN2RAB9AKDM4EMAPT | |
| SCHEMBL2914500 | 0.77 | PSMB5 (0.46) | POLBSMN1; SMN2RAB9AKDM4EMAPT | |
| SCHEMBL17385281 | 0.77 | GAA (0.51) | POLBSMN1; SMN2RAB9AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2750504-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC Therapeutics, Inc. (US) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013033258-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC THERAPEUTICS, INC. (US) | 2013-03-07 | — | — | WO | disclosed |