Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28079882 | 0.90 | LMNA (0.35) | LMNABLMPDE4APTGS1SLC6A6 | |
| Piperidine SCHEMBL29554180 | 0.88 | ALDH1A1 (0.41) | LMNABLMPDE4APTGS1SLC6A6 | |
| Piperazine SCHEMBL28134580 | 0.86 | LMNA (0.43) | LMNABLMPDE4APTGS1SLC6A6 | |
| Morpholine SCHEMBL14742144 | 0.84 | MEN1 (0.44) | LMNABLMPDE4APTGS1SLC6A6 | |
| SCHEMBL827 | 0.83 | — | — | |
| SCHEMBL249947 | 0.83 | LMNA (0.50) | LMNABLMPDE4APTGS1SLC6A6 | |
| SCHEMBL1138826 | 0.80 | — | — | |
| SCHEMBL4306610 | 0.80 | — | — | |
| SCHEMBL9001614 | 0.80 | — | — | |
| SCHEMBL1304651 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114246872-B | Technological method and composition for improving fluidity of isethionic acid piperazine Bai Xili | 南京济群医药科技股份有限公司 | 2024-02-06 | — | — | CN | claimed |
| CN-114246841-B | Composition and medicine of isethionic acid piperdine Bai Xi | 南京济群医药科技股份有限公司 | 2024-02-02 | — | — | CN | claimed |
| CN-112375733-B | Phytohemagglutinin capable of improving stem cell performance of mesenchymal stem cells and application of phytohemagglutinin in amplification culture of mesenchymal stem cells | 中国人民解放军陆军军医大学第一附属医院 | 2022-09-02 | — | — | CN | claimed |
| CN-112300985-B | Proliferation culture medium and proliferation culture method for rapidly improving proliferation efficiency of mesenchymal stem cells of mammals | 中国人民解放军陆军军医大学第一附属医院 | 2022-07-01 | — | — | CN | claimed |
| CN-112375733-A | Phytohemagglutinin capable of improving stem cell performance of mesenchymal stem cells and application of phytohemagglutinin in mesenchymal stem cell amplification culture | 中国人民解放军陆军军医大学第一附属医院 | 2021-02-19 | — | — | CN | claimed |
| CN-112300985-A | Proliferation culture medium and proliferation culture method for rapidly improving proliferation efficiency of mesenchymal stem cells of mammals | 中国人民解放军陆军军医大学第一附属医院 | 2021-02-02 | — | — | CN | claimed |
| CN-114246872-B | Technological method and composition for improving fluidity of isethionic acid piperazine Bai Xili | 南京济群医药科技股份有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-114246872-B | Technological method and composition for improving fluidity of isethionic acid piperazine Bai Xili | 南京济群医药科技股份有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-114246872-B | Technological method and composition for improving fluidity of isethionic acid piperazine Bai Xili | 南京济群医药科技股份有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-114246841-B | Composition and medicine of isethionic acid piperdine Bai Xi | 南京济群医药科技股份有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-114246841-B | Composition and medicine of isethionic acid piperdine Bai Xi | 南京济群医药科技股份有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-112375733-B | Phytohemagglutinin capable of improving stem cell performance of mesenchymal stem cells and application of phytohemagglutinin in amplification culture of mesenchymal stem cells | 中国人民解放军陆军军医大学第一附属医院 | 2022-09-02 | — | — | CN | disclosed |
| CN-112300985-B | Proliferation culture medium and proliferation culture method for rapidly improving proliferation efficiency of mesenchymal stem cells of mammals | 中国人民解放军陆军军医大学第一附属医院 | 2022-07-01 | — | — | CN | disclosed |
| CN-114246841-A | Composition and medicine of piperazine isethionate and quinapride | 南京济群医药科技股份有限公司 | 2022-03-29 | — | — | CN | disclosed |
| CN-114246841-A | Composition and medicine of piperazine isethionate and quinapride | 南京济群医药科技股份有限公司 | 2022-03-29 | — | — | CN | disclosed |
| CN-114246841-A | Composition and medicine of piperazine isethionate and quinapride | 南京济群医药科技股份有限公司 | 2022-03-29 | — | — | CN | disclosed |
| CN-112375733-A | Phytohemagglutinin capable of improving stem cell performance of mesenchymal stem cells and application of phytohemagglutinin in mesenchymal stem cell amplification culture | 中国人民解放军陆军军医大学第一附属医院 | 2021-02-19 | — | — | CN | disclosed |
| CN-112300985-A | Proliferation culture medium and proliferation culture method for rapidly improving proliferation efficiency of mesenchymal stem cells of mammals | 中国人民解放军陆军军医大学第一附属医院 | 2021-02-02 | — | — | CN | disclosed |
| WO-2013033046-A2 | FLUORESCENT PL MARKERS FOR ISOELECTRIC FOCUSING SEPARATIONS AND FLUORESCENT LABELING | VIGH GYULA (US) | 2013-03-07 | — | — | WO | disclosed |