Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14742283 | 0.90 | IMPDH2 (0.33) | IMPDH2PIK3CDSLC2A1 | |
| SCHEMBL14742212 | 0.83 | HTR2C (0.33) | IMPDH2PIK3CD | |
| SCHEMBL14742518 | 0.79 | IMPDH2 (0.37) | IMPDH2PIK3CD | |
| SCHEMBL14742440 | 0.79 | PIK3CD (0.33) | PIK3CD | |
| SCHEMBL14742657 | 0.77 | IMPDH2 (0.36) | IMPDH2PIK3CD | |
| SCHEMBL14736161 | 0.75 | PIK3CD (0.41) | PIK3CD | |
| SCHEMBL14736186 | 0.75 | PIK3CD (0.41) | PIK3CD | |
| SCHEMBL14742311 | 0.74 | DRD2 (0.44) | PIK3CD | |
| SCHEMBL14742563 | 0.74 | IMPDH2 (0.33) | IMPDH2PIK3CDSLC2A1 | |
| SCHEMBL15995059 | 0.72 | TGFBR1 (0.36) | IMPDH2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2961410-A1 | USE OF PYRAZOLOPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PI3K RELATED DISORDERS | Incyte Holdings Corporation (US) | 2016-01-06 | — | — | EP | disclosed |
| WO-2014134426-A1 | USE OF PYRAZOLOPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PI3Kδ RELATED DISORDERS | INCYTE CORPORATION (US) | 2014-09-04 | — | — | WO | disclosed |
| EP-2751109-A1 | HETEROCYCLYLAMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013033569-A1 | HETEROCYCLYLAMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2013-03-07 | — | — | WO | disclosed |