Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 8/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 5/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.39 |
| ▸ | GRIK3 | Q13003 | 4/20 | 0.39 |
| ▸ | GRIK5 | Q16478 | 4/20 | 0.39 |
| ▸ | BHMT | Q93088 | 1/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL14742424 | 1.00 | MEN1 (0.44) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Asparagine SCHEMBL28252681 | 0.87 | KMT2A (0.43) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Aspartic Acid SCHEMBL6033509 | 0.85 | LMNA (0.41) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL1683101 | 0.84 | KMT2A (0.48) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL1683106 | 0.84 | KMT2A (0.48) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Leucine SCHEMBL28252682 | 0.83 | SLC7A5 (0.67) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Glutamic Acid SCHEMBL10623303 | 0.81 | GRM8 (0.64) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| D-Glutamate SCHEMBL10623300 | 0.81 | GRM8 (0.64) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL22345960 | 0.81 | LMNA (0.55) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Aspartic Acid SCHEMBL14742381 | 0.81 | GRIK1 (0.50) | SLC7A5GRIK1GRIK2SLC1A1GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013033046-A2 | FLUORESCENT PL MARKERS FOR ISOELECTRIC FOCUSING SEPARATIONS AND FLUORESCENT LABELING | VIGH GYULA (US) | 2013-03-07 | — | — | WO | disclosed |