Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16505119 | 0.79 | LMNA (0.66) | LMNAKDM4EPIM1PIM3PIM2 | |
| SCHEMBL14743222 | 0.75 | SCN9A (0.45) | KDM4EKMT2AMEN1 | |
| SCHEMBL14358700 | 0.74 | LMNA (1.00) | LMNAPIM1PIM3PIM2GRM2 | |
| SCHEMBL16506027 | 0.74 | LMNA (0.58) | LMNAPIM1PIM3PIM2GRM2 | |
| SCHEMBL14754514 | 0.72 | LMNA (0.66) | LMNAKDM4EPIM1PIM3PIM2 | |
| SCHEMBL16506138 | 0.71 | LMNA (0.50) | LMNAKDM4EGRM2DPP4NQO2 | |
| SCHEMBL23715745 | 0.70 | KDM4E (0.44) | LMNAKDM4EMAPTHTTKMT2A | |
| SCHEMBL1178392 | 0.70 | LMNA (0.73) | LMNAPIM1PIM3PIM2GRM2 | |
| SCHEMBL3659442 | 0.69 | LMNA (0.79) | LMNAPIM1PIM3PIM2GRM2 | |
| SCHEMBL16505676 | 0.68 | LMNA (0.76) | LMNAPIM1PIM3PIM2GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964639-A1 | PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS | Purdue Pharma LP (US) | 2016-01-13 | — | — | EP | disclosed |
| WO-2014135955-A1 | PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. (US) | 2014-09-12 | — | — | WO | disclosed |
| WO-2013030665-A1 | PYRIMIDINES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. (US) | 2013-03-07 | — | — | WO | disclosed |