Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 18/20 | 0.45 |
| ▸ | FPR2 | P25090 | 9/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14743343 | 0.80 | SCN9A (0.59) | SCN9AFPR2KDM4E | |
| SCHEMBL14743144 | 0.75 | LMNA (0.56) | KDM4EMEN1KMT2A | |
| SCHEMBL19072510 | 0.68 | FPR2 (0.69) | SCN9AFPR2 | |
| SCHEMBL7575874 | 0.67 | ALDH1A1 (0.47) | MEN1KMT2A | |
| SCHEMBL19945965 | 0.67 | FPR2 (0.70) | SCN9AFPR2 | |
| SCHEMBL14743323 | 0.67 | FPR2 (0.70) | SCN9AFPR2 | |
| SCHEMBL4829425 | 0.60 | KDM4E (0.60) | KDM4EMEN1KMT2A | |
| SCHEMBL195531 | 0.60 | MEN1 (0.68) | KDM4EMEN1KMT2A | |
| SCHEMBL21236828 | 0.59 | SCN9A (0.47) | SCN9AKDM4EMEN1KMT2A | |
| SCHEMBL27616905 | 0.59 | HSP90AB1 (0.37) | KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964639-A1 | PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS | Purdue Pharma LP (US) | 2016-01-13 | — | — | EP | disclosed |
| WO-2014135955-A1 | PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. (US) | 2014-09-12 | — | — | WO | disclosed |
| WO-2013030665-A1 | PYRIMIDINES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. (US) | 2013-03-07 | — | — | WO | disclosed |