Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23715885 | 0.83 | SCN9A (0.35) | KDM4EKMT2AKMOTDP1GPR35 | |
| SCHEMBL1425683 | 0.81 | ALOX15 (0.38) | KDM4EKMT2ATDP1GPR35ALOX15 | |
| SCHEMBL7878295 | 0.75 | LMNA (0.62) | KDM4EKMOTDP1LMNAGPR35 | |
| SCHEMBL1603021 | 0.74 | KMT2A (0.67) | KDM4EKMT2ATDP1MAPTTP53 | |
| SCHEMBL17281038 | 0.74 | KMO (0.45) | KDM4EKMT2AKMOTDP1LMNA | |
| SCHEMBL11677713 | 0.73 | KMT2A (0.51) | KDM4EKMT2ATDP1ALOX15TSHR | |
| SCHEMBL3114617 | 0.73 | PIK3CA (0.48) | KDM4ELMNAHTTNAPEPLD | |
| SCHEMBL3407231 | 0.73 | KMT2A (0.62) | KDM4EKMT2ALMNAMAPTHTT | |
| SCHEMBL12484062 | 0.72 | KMT2A (0.46) | KDM4EKMT2AHTTCRHR1 | |
| SCHEMBL23715962 | 0.72 | KMT2A (0.51) | KDM4EKMT2ALMNAMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021152149-A1 | RAS INHIBITORS AND METHODS OF USING THE SAME | JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) | 2021-08-05 | — | — | WO | disclosed |