Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14743471 | 0.90 | PYGL (0.49) | PYGLALDH1A1HPGDDPP4DPP8 | |
| SCHEMBL14743648 | 0.82 | PYGL (0.52) | PYGLALDH1A1HPGDKDM4EPDK1 | |
| SCHEMBL14743080 | 0.82 | KMT2A (0.47) | ALDH1A1HPGDLMNASMN1; SMN2 | |
| SCHEMBL14743950 | 0.80 | PYGL (0.46) | PYGLALDH1A1HPGDLMNADPP4 | |
| SCHEMBL14744312 | 0.78 | NOTUM (0.51) | ALDH1A1LMNATP53NAMPTSMN1; SMN2 | |
| SCHEMBL14742999 | 0.77 | KDM4C (0.45) | LMNA | |
| SCHEMBL14743813 | 0.74 | KMT2A (0.44) | ALDH1A1HPGDLMNAKDM4E | |
| SCHEMBL14743400 | 0.73 | KMT2A (0.51) | ALDH1A1HPGDLMNANAMPTKDM4E | |
| SCHEMBL14743685 | 0.73 | KCNMA1 (0.55) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL14743424 | 0.72 | TDP1 (0.52) | ALDH1A1HPGDLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013030358-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2013-03-07 | — | — | WO | claimed |
| WO-2013030358-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2013-03-07 | — | — | WO | disclosed |