Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
| ▸ | TPMT | P51580 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | PPM1G | O15355 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | PPM1A | P35813 | 1/20 | 0.33 |
| ▸ | PTPN9 | P43378 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.33 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.32 |
| ▸ | KDM4A | O75164 | 1/20 | 0.32 |
| ▸ | KDM4B | O94953 | 1/20 | 0.32 |
| ▸ | KDM5C | P41229 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14743489 | 0.84 | GAA (0.41) | ACLYGPBAR1GRM4NPC1RAB9A | |
| SCHEMBL14743590 | 0.83 | GPBAR1 (0.40) | KDM4EGPBAR1ALDH1A1 | |
| SCHEMBL14743459 | 0.82 | ACLY (0.36) | ACLYTPMTGPBAR1NR1H4NPC1 | |
| SCHEMBL14744302 | 0.81 | ACLY (0.46) | ACLYTPMTGPBAR1NPC1ALDH1A1 | |
| SCHEMBL14743638 | 0.80 | CYP1A2 (0.35) | ACLYTPMTGPBAR1GRM4ALDH1A1 | |
| SCHEMBL14743375 | 0.80 | GPBAR1 (0.39) | ACLYGPBAR1GRM4 | |
| SCHEMBL14743703 | 0.80 | ACLY (0.35) | ACLYGPBAR1NR1H4NPC1ALDH1A1 | |
| SCHEMBL14743723 | 0.79 | KDM4E (0.47) | KDM4EACLYGPBAR1GRM1 | |
| SCHEMBL14743805 | 0.76 | GPBAR1 (0.43) | KDM4EGPBAR1NPC1ALDH1A1HTT | |
| SCHEMBL14743833 | 0.72 | MAPT (0.38) | ACLYALOX5NPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013030358-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2013-03-07 | — | — | WO | disclosed |