Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14737751 | 1.00 | AR (0.36) | ARLMNAPOLBFDPSTHRB | |
| SCHEMBL30171197 | 0.72 | AR (0.46) | ARLMNAPOLBFDPSTDP1 | |
| SCHEMBL18982195 | 0.71 | THRB (0.37) | ARLMNAPOLBFDPSTHRB | |
| SCHEMBL16861331 | 0.70 | FDPS (0.36) | ARFDPSTDP1MEN1KMT2A | |
| SCHEMBL29268091 | 0.70 | AR (0.37) | ARLMNAPOLBFDPSMEN1 | |
| SCHEMBL18338440 | 0.70 | CYP4F2 (0.39) | ARLMNAFDPSTHRBMEN1 | |
| SCHEMBL18338554 | 0.68 | HTT (0.40) | ARLMNAPOLBFDPSTHRB | |
| SCHEMBL20404649 | 0.68 | HTT (0.40) | ARLMNAPOLBFDPSTHRB | |
| SCHEMBL27726640 | 0.68 | FDPS (0.37) | ARFDPSTHRBTDP1MEN1 | |
| SCHEMBL1444746 | 0.67 | FDPS (0.40) | ARFDPSMEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |