Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | WNT1 | P04628 | 1/20 | 0.30 |
| ▸ | CLK2 | P49760 | 1/20 | 0.30 |
| ▸ | CLK3 | P49761 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14744385 | 0.86 | MAPT (0.33) | SYKMAPTMAPK1DGAT1 | |
| SCHEMBL14738846 | 0.79 | DGAT1 (0.32) | MAPTMAPK1DGAT1 | |
| SCHEMBL14737439 | 0.79 | MAPK1 (0.32) | SYKMAPTMAPK1DGAT1 | |
| SCHEMBL14744496 | 0.79 | DGAT1 (0.32) | DGAT1 | |
| SCHEMBL14747034 | 0.79 | PDE4A (0.37) | MAPTMAPK1 | |
| SCHEMBL14738453 | 0.79 | SYK (0.48) | SYKMAPTDGAT1 | |
| SCHEMBL14737264 | 0.77 | SYK (0.62) | SYKLRRK2DYRK1ADGAT1 | |
| SCHEMBL14737725 | 0.77 | SYK (0.37) | SYKMAPTDGAT1 | |
| SCHEMBL14744517 | 0.77 | SYK (0.42) | SYKMAPTMAPK1DYRK1ADGAT1 | |
| SCHEMBL14752058 | 0.76 | MAP2K4 (0.38) | LRRK2MAPK1DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853219-B2 | Compounds and compositions for cognition-enhancement, methods of making, and methods of treating | NEUROSOLIS, INC. (US) | 2014-10-07 | — | — | US | disclosed |
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |