Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.30 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14737582 | 0.89 | TTK (0.33) | ATRSIRT2 | |
| SCHEMBL14737474 | 0.84 | LMNA (0.38) | ATRRET | |
| SCHEMBL14744503 | 0.82 | ATR (0.33) | ATRSIRT2MAPK8 | |
| SCHEMBL14737300 | 0.82 | LMNA (0.38) | SIRT2 | |
| SCHEMBL14751438 | 0.77 | EGLN1 (0.33) | — | |
| SCHEMBL14737274 | 0.76 | ADORA3 (0.31) | SIRT2 | |
| SCHEMBL14331979 | 0.71 | ADORA1 (0.34) | ATR | |
| SCHEMBL16176675 | 0.71 | MAPK1 (0.35) | — | |
| SCHEMBL14331972 | 0.71 | ALDH1A1 (0.35) | ATR | |
| SCHEMBL14331938 | 0.69 | ADORA3 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |