Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21223465 | 0.87 | NUDT1 (0.43) | BACE1ENPP1 | |
| SCHEMBL29496134 | 0.77 | NPC1 (0.51) | BACE1HSP90AA1HSP90AB1KDM4ENPC1 | |
| SCHEMBL263446 | 0.77 | NPC1 (0.51) | BACE1HSP90AA1HSP90AB1KDM4ENPC1 | |
| SCHEMBL29559935 | 0.76 | BACE1 (0.40) | BACE1KDM4ENPC1RAB9AMEN1 | |
| SCHEMBL19456705 | 0.76 | BACE1 (0.40) | BACE1KDM4ENPC1RAB9AMEN1 | |
| SCHEMBL4501032 | 0.74 | BACE1 (0.49) | BACE1HSP90AA1HSP90AB1KDM4ENPC1 | |
| Ammonia Solution, Strong SCHEMBL7878002 | 0.72 | BACE1 (0.50) | BACE1HSP90AA1HSP90AB1KDM4ENPC1 | |
| SCHEMBL29496028 | 0.71 | BACE1 (0.46) | BACE1HSP90AA1HSP90AB1KDM4ENPC1 | |
| SCHEMBL30063182 | 0.66 | BACE1 (0.41) | BACE1KDM4EMAPTKMT2AALDH1A1 | |
| SCHEMBL1262778 | 0.66 | HSD11B1 (0.59) | KDM4EMEN1KMT2AHSD11B1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013029338-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2013-03-07 | — | — | WO | disclosed |