SCHEMBL14744293

SCHEMBL14744293

CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(Br)c(C)n2)cc1

nearest known ligand 0.53

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 2/20 0.53
RORC P51449 17/20 0.50
NPC1 O15118 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14743966 0.89 RAB9A (0.54) RAB9ARORCNPC1
SCHEMBL14744156 0.88 RORC (0.50) RAB9ARORCNPC1
SCHEMBL14743974 0.84 RORC (0.49) RORC
SCHEMBL14744122 0.83 RORC (0.52) RORC
SCHEMBL14744062 0.79 RORC (0.51) RORC
SCHEMBL14744334 0.77 RORC (0.51) RORC
SCHEMBL14744550 0.77 RORC (0.62) RORC
SCHEMBL14754267 0.75 RORC (0.55) RORC
SCHEMBL14744303 0.75 RORC (0.53) RORC
SCHEMBL14744307 0.74 RORC (0.70) RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013029338-A1 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2013-03-07 WO disclosed