Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5744835 | 0.73 | HRH2 (0.44) | HRH2HRH1LTA4HSMN1; SMN2HRH3 | |
| SCHEMBL20838985 | 0.71 | HRH2 (0.35) | HRH2HRH1 | |
| SCHEMBL20838978 | 0.71 | HRH2 (0.35) | HRH2HRH1 | |
| SCHEMBL21063385 | 0.71 | SMN1; SMN2 (0.33) | SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL28249295 | 0.70 | HRH2 (0.41) | HRH2HRH1SMN1; SMN2HRH3 | |
| Trifluoroacetic Acid SCHEMBL28249916 | 0.70 | HRH2 (0.39) | HRH2HRH1LTA4HHRH3 | |
| SCHEMBL24675480 | 0.70 | HRH2 (0.49) | HRH2HRH1LTA4HSMN1; SMN2HRH3 | |
| SCHEMBL3604108 | 0.69 | SLC18A3 (0.35) | SMN1; SMN2HTT | |
| SCHEMBL4056780 | 0.69 | SLC18A3 (0.35) | SMN1; SMN2HTT | |
| Trifluoroacetic Acid SCHEMBL28249292 | 0.68 | GNAI3 (0.47) | HRH2HRH1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |