Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 9/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.41 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.41 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1411551 | 0.81 | PTGS1 (0.46) | EPAS1 | |
| SCHEMBL8500197 | 0.81 | EPAS1 (0.40) | CNR2EPAS1TRPV4PDE4APDE4C | |
| SCHEMBL18482393 | 0.81 | ALPL (0.44) | ALPL | |
| SCHEMBL8359389 | 0.80 | EPAS1 (0.46) | EPAS1PDE4APDE4CPDE4D | |
| SCHEMBL31204476 | 0.79 | TSHR (0.46) | EPAS1PDE4APDE4CPDE4D | |
| SCHEMBL2004462 | 0.78 | ALDH1A1 (0.41) | — | |
| SCHEMBL28994364 | 0.78 | PTGS1 (0.50) | EPAS1 | |
| SCHEMBL16396491 | 0.78 | RXRA (0.43) | ALPL | |
| SCHEMBL10692079 | 0.77 | ALPL (0.49) | ALPLCNR2EPAS1ACLYTRPV4 | |
| SCHEMBL14995469 | 0.76 | KDM4E (0.46) | EPAS1TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013029338-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2013-03-07 | — | — | WO | disclosed |