SCHEMBL147448

SCHEMBL147448

O=c1[nH]c2cccc(Cl)c2c(=O)o1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F2 P00734 1/20 0.52
CFD P00746 1/20 0.52
ERCC5 P28715 1/20 0.47
FEN1 P39748 1/20 0.47
OGT O15294 1/20 0.46
GRIN2D O15399 2/20 0.44
GRIN3B O60391 2/20 0.44
GRIN1 Q05586 2/20 0.44
GRIN2A Q12879 2/20 0.44
GRIN2B Q13224 2/20 0.44
GRIN2C Q14957 2/20 0.44
GRIN3A Q8TCU5 2/20 0.44
DYRK1A Q13627 1/20 0.44
KMO O15229 1/20 0.43
CHEK1 O14757 1/20 0.42
PBRM1 Q86U86 1/20 0.41
ELANE P08246 3/20 0.41
PSMB8 P28062 1/20 0.41
LMNA P02545 1/20 0.41
CYP1A2 P05177 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27701688 0.88 F2 (0.41) F2CFDERCC5FEN1OGT
SCHEMBL26239054 0.78 F2 (0.52) F2CFDFEN1OGTGRIN2D
SCHEMBL8872031 0.78 GRIN2D (0.44) F2CFDOGTGRIN2DGRIN3B
SCHEMBL5310423 0.78 F2 (0.52) F2CFDOGTLMNACYP1A2
SCHEMBL3498795 0.78 F2 (0.52) F2CFDFEN1OGTELANE
SCHEMBL17203101 0.78 F2 (0.52) F2CFDOGTELANEPSMB8
SCHEMBL8573976 0.78 CYP1A2 (0.49) F2CFDGRIN2DGRIN3BGRIN1
SCHEMBL3987671 0.78 F2 (0.52) F2CFDOGTCHEK1LMNA
SCHEMBL1203402 0.78 F2 (0.52) F2CFDFEN1OGTELANE
SCHEMBL619937 0.78 F2 (0.52) F2CFDOGTELANECYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 326 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118910629-A Electrochemical synthesis method of quinazolinone derivative 齐齐哈尔医学院 2024-11-08 CN claimed
US-8202989-B2 One step process for the preparation of substituted 5, 10-dihydrodibenzo [b,e][1, 4]diazepine-11-ones COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2012-06-19 US claimed
US-20100228023-A1 ONE STEP PROCESS FOR THE PREPARATION OF SUBSTITUTED 5, 10-DIHYDRODIBENZO [b,e][1, 4]DIAZEPINE-11-ONES COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2010-09-09 US claimed
EP-0315138-B1 PROCESS FOR THE PREPARATION OF 6-CHLOROISATOIC ANHYDRIDE HOECHST AKTIENGESELLSCHAFT (DE) 1993-01-27 EP claimed
EP-0315138-A1 Process for the preparation of 6-chloroisatoic anhydride HOECHST AKTIENGESELLSCHAFT (DE) 1989-05-10 EP claimed
EP-4727923-A1 TETRAHYDROACRIDINONE ANALOGUES FOR TREATMENT AND PREVENTION OF MALARIA University of Georgia Research Foundation, Inc. (US) 2026-04-22 EP disclosed
US-20260098012-A1 TETRAHYDROACRIDINONE ANALOGUES FOR TREATMENT AND PREVENTION OF MALARIA UNIV GEORGIA (US) 2026-04-09 US disclosed
US-12365762-B2 Dispersant for coating system BASF SE (DE) 2025-07-22 US disclosed
WO-2024255845-A1 PROTEIN DEGRADATION AGENT, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF 中国科学院上海药物研究所 2024-12-19 WO disclosed
WO-2024258904-A1 TETRAHYDROACRIDINONE ANALOGUES FOR TREATMENT AND PREVENTION OF MALARIA UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2024-12-19 WO disclosed
CN-119143748-A Protein degradation agent, pharmaceutical composition and application thereof 中国科学院上海药物研究所 2024-12-17 CN disclosed
CN-118910629-A Electrochemical synthesis method of quinazolinone derivative 齐齐哈尔医学院 2024-11-08 CN disclosed
US-4316839-A Imidazodiazepine derivatives HOFFMAN-LA ROCHE INC. (US) 1982-02-23 US disclosed
US-4306074-A Preparation of a mixture of an alkyl 3-chloroanthranilate and an alkyl 6-chloroanthranilate BASF AKTIENGESELLSCHAFT (DE) 1981-12-15 US disclosed
EP-0027214-A1 Imidazodiazepine derivatives, process and intermediates for their preparation, medicaments containing them and their therapeutic application F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1981-04-22 EP disclosed
EP-0020969-A1 Process for the preparation of a mixture of 3-chloro-anthranilic acid alkyl ester and 6-chloro-anthranilic acid alkyl ester BASF Aktiengesellschaft (DE) 1981-01-07 EP disclosed
US-4154755-A Manufacture of N-(2-cyanophenyl)-formamidines BASF AKTIENGESELLSCHAFT (DE) 1979-05-15 US disclosed
US-4041025-A FOR HYDROPHOBIC FIBERS SUCH AS POLYESTERS, YELLOW TO BLUE-GREEN SHADES BASF AKTIENGESELLSCHAFT (DT) 1977-08-09 US disclosed
US-3984406-A FROM AN ALKALI METAL PHTHALAMATE AND A HYPOHALITE IN A HALOGEN CATALYST BASF AKTIENGESELLSCHAFT (DT) 1976-10-05 US disclosed
US-3937704-A 3-(METHYLSULFINYL)CINNOLINONES AND THEIR DERIVATIVES WARNER-LAMBERT COMPANY (US) 1976-02-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100228023-A1 ONE STEP PROCESS FOR THE PREPARATION OF SUBSTITUTED 5, 10-DIHYDRODIBENZO [b,e][1, 4]DIAZEPINE-11-ONES BBOX1, CYP1B1, CYP4B1 F2 2071/4885CFD 3415/4885ERCC5 2323/4885
US-20260098012-A1 TETRAHYDROACRIDINONE ANALOGUES FOR TREATMENT AND PREVENTION OF MALARIA CD47, SLC11A2, G6PD F2 1060/4885CFD 398/4885ERCC5 3708/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.