Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 1/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 4/20 | 0.32 |
| ▸ | MPL | P40238 | 1/20 | 0.30 |
| ▸ | BCL2 | P10415 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14745245 | 0.90 | MTNR1A (0.35) | PPARGMPL | |
| SCHEMBL17597216 | 0.89 | CYP19A1 (0.34) | PPARG | |
| SCHEMBL14744763 | 0.87 | BCL2 (0.36) | PPARGBCL2MCL1 | |
| SCHEMBL14745764 | 0.87 | SERPINE1 (0.31) | PRKAG1PRKAA2PRKAA1PRKAB1PPARG | |
| SCHEMBL17597693 | 0.86 | PTGER3 (0.32) | MPL | |
| SCHEMBL14745471 | 0.86 | PTGER3 (0.37) | PRKAG1PRKAA2PRKAA1PRKAB1 | |
| SCHEMBL17597212 | 0.84 | GRK5 (0.40) | PRKAG1PRKAA2PRKAA1PRKAB1MCL1 | |
| SCHEMBL14744943 | 0.83 | PRKAG1 (0.40) | PRKAG1PRKAA2PRKAA1PRKAB1 | |
| SCHEMBL14745804 | 0.81 | TUBB4A (0.36) | PPARG | |
| SCHEMBL17597597 | 0.80 | USP7 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2750504-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC Therapeutics, Inc. (US) | 2014-07-09 | — | — | EP | claimed |
| WO-2013033258-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC THERAPEUTICS, INC. (US) | 2013-03-07 | — | — | WO | claimed |