Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14745059 | 0.91 | ALOX5 (0.30) | PDE3BPDE3AALOX5 | |
| SCHEMBL14745770 | 0.89 | PDE3B (0.31) | PDE3BPDE3A | |
| SCHEMBL14745054 | 0.80 | — | — | |
| SCHEMBL14741084 | 0.77 | ALDH1A1 (0.33) | PDE3BPDE3AALDH1A1HSD17B10KDM4E | |
| SCHEMBL17594967 | 0.76 | ALDH1A1 (0.37) | PDE3BPDE3AALDH1A1KDM4EMEN1 | |
| SCHEMBL14741160 | 0.73 | KDM4E (0.41) | PDE3BPDE3AALDH1A1HSD17B10KDM4E | |
| SCHEMBL14741182 | 0.73 | KDM4E (0.34) | ALDH1A1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL17597373 | 0.73 | GSK3B (0.39) | KDM4E | |
| SCHEMBL17595256 | 0.73 | PDE3B (0.35) | PDE3BPDE3AALDH1A1HSD17B10KDM4E | |
| SCHEMBL14740869 | 0.71 | PDE3B (0.38) | PDE3BPDE3AALDH1A1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2750505-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC Therapeutics, Inc. (US) | 2014-07-09 | — | — | EP | claimed |
| WO-2013033240-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC THERAPEUTICS, INC. (US) | 2013-03-07 | — | — | WO | claimed |