Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17595254 | 0.86 | MEN1 (0.38) | PDE3BPDE3AGSK3BMAPTKDM4E | |
| SCHEMBL17594871 | 0.82 | ALDH1A1 (0.39) | PDE3BPDE3AMAPTALDH1A1LMNA | |
| SCHEMBL17594971 | 0.81 | LMNA (0.39) | PDE3BPDE3AMAPTALDH1A1LMNA | |
| SCHEMBL17595782 | 0.81 | PDE3B (0.34) | PDE3BPDE3AMAPTKDM4E | |
| SCHEMBL14740984 | 0.80 | MEN1 (0.39) | GSK3BMAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL17597694 | 0.79 | PTGER3 (0.31) | PDE3BPDE3A | |
| SCHEMBL17597217 | 0.78 | MTNR1A (0.33) | PDE3BPDE3A | |
| SCHEMBL17595374 | 0.78 | AURKA (0.33) | PDE3BPDE3AKDM4E | |
| SCHEMBL17594958 | 0.77 | PDE3B (0.48) | PDE3BPDE3AMAPTKDM4EALDH1A1 | |
| SCHEMBL14741112 | 0.77 | HPGD (0.42) | PDE3BPDE3AGSK3BMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016039936-A2 | MONOCYCLIC SUBSTITUTED 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | claimed |