Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.41 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.30 |
| ▸ | MPL | P40238 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14745498 | 0.91 | PDE3B (0.41) | PDE3BPDE3APRNPCYP1A2CYP2C9 | |
| SCHEMBL14740980 | 0.86 | PDE3B (0.41) | PDE3BPDE3APRNPCYP1A2CYP2C9 | |
| SCHEMBL14741096 | 0.85 | AURKA (0.36) | PDE3BPDE3APPARGTNIK | |
| SCHEMBL14741243 | 0.84 | PDE3B (0.50) | PDE3BPDE3APRNPCYP1A2CYP2C9 | |
| SCHEMBL14745816 | 0.83 | PDE3B (0.43) | PDE3BPDE3APRNPCYP1A2CYP2C9 | |
| SCHEMBL14745238 | 0.83 | SERPINE1 (0.42) | PDE3BPDE3A | |
| SCHEMBL17595254 | 0.83 | MEN1 (0.38) | PDE3BPDE3AHIF1ANPSR1CNR2 | |
| SCHEMBL14741107 | 0.82 | KDM4E (0.41) | PDE3BPDE3ARXFP1CNR2TNIK | |
| SCHEMBL17594868 | 0.80 | KIF11 (0.38) | PDE3BPDE3ASIRT1 | |
| SCHEMBL14745819 | 0.80 | GSK3B (0.43) | PDE3BPDE3ARXFP1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016039936-A2 | MONOCYCLIC SUBSTITUTED 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | claimed |
| EP-2750505-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC Therapeutics, Inc. (US) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013033240-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC THERAPEUTICS, INC. (US) | 2013-03-07 | — | — | WO | disclosed |