Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 5/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14745819 | 0.90 | GSK3B (0.43) | SERPINE1PDE3BPDE3AKDM4EGAA | |
| SCHEMBL14740973 | 0.87 | SERPINE1 (0.47) | SERPINE1DHODHKDM4EGAA | |
| SCHEMBL14741114 | 0.84 | SERPINE1 (0.42) | SERPINE1PDE3BPDE3AKDM4EGAA | |
| SCHEMBL17595254 | 0.84 | MEN1 (0.38) | PDE3BPDE3AKDM4EGAA | |
| SCHEMBL14745239 | 0.83 | PDE3B (0.43) | SERPINE1DHODHPDE3BPDE3A | |
| SCHEMBL14745815 | 0.83 | PDE3B (0.41) | PDE3BPDE3A | |
| SCHEMBL14745498 | 0.82 | PDE3B (0.41) | SERPINE1DHODHPDE3BPDE3AGAA | |
| SCHEMBL17594868 | 0.81 | KIF11 (0.38) | SERPINE1DHODHPDE3BPDE3A | |
| SCHEMBL14741008 | 0.81 | PDE3B (0.52) | SERPINE1DHODHPDE3BPDE3AKDM4E | |
| SCHEMBL17594969 | 0.81 | KIF11 (0.39) | DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016039936-A2 | MONOCYCLIC SUBSTITUTED 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | claimed |
| EP-2750505-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC Therapeutics, Inc. (US) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013033240-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC THERAPEUTICS, INC. (US) | 2013-03-07 | — | — | WO | disclosed |