Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14745238 | 0.90 | SERPINE1 (0.42) | KDM4EGAASERPINE1PDE3BPDE3A | |
| SCHEMBL14741120 | 0.86 | KDM4E (0.45) | GSK3BKDM4EGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL14745820 | 0.85 | SMN1; SMN2 (0.38) | GSK3BKDM4EGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL14740973 | 0.84 | SERPINE1 (0.47) | KDM4EGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL14741167 | 0.84 | KDM4E (0.57) | KDM4EGAAALDH1A1SMN1; SMN2RXFP1 | |
| SCHEMBL14741114 | 0.81 | SERPINE1 (0.42) | KDM4EGAACNR2MAPTHTT | |
| SCHEMBL17595254 | 0.81 | MEN1 (0.38) | GSK3BKDM4EGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL14745815 | 0.80 | PDE3B (0.41) | RXFP1CNR2PDE3BPDE3A | |
| SCHEMBL14745498 | 0.79 | PDE3B (0.41) | GAARXFP1PKMSERPINE1PDE3B | |
| SCHEMBL17594868 | 0.78 | KIF11 (0.38) | ALDH1A1PRKAG1PRKAA1PRKAB1SERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2750505-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC Therapeutics, Inc. (US) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013033240-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC THERAPEUTICS, INC. (US) | 2013-03-07 | — | — | WO | disclosed |