Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.53 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | PDE5A | O76074 | 18/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19480647 | 0.91 | PDE5A (0.59) | GUCY1A1GUCY1B1KCNH2PDE5A | |
| SCHEMBL14746629 | 0.90 | PDE5A (0.53) | PDE5A | |
| SCHEMBL14746248 | 0.86 | PDE5A (0.63) | PDE5A | |
| SCHEMBL14754751 | 0.83 | PDE5A (0.49) | PDE5A | |
| SCHEMBL17324493 | 0.82 | GUCY1A1 (0.53) | GUCY1A1GUCY1B1KCNH2PDE5A | |
| SCHEMBL3575506 | 0.78 | L3MBTL1 (0.42) | — | |
| SCHEMBL3579101 | 0.77 | NPC1 (0.41) | GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL2450847 | 0.76 | GUCY1A1 (0.57) | GUCY1A1GUCY1B1KCNH2PDE5A | |
| SCHEMBL2451805 | 0.76 | GUCY1A1 (0.62) | GUCY1A1GUCY1B1KCNH2PDE5A | |
| SCHEMBL14788248 | 0.75 | GUCY1A1 (0.48) | GUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751106-B1 | SUBSTITUTED ANNELLATED PYRIMIDINE AND THE USE THEREOF | BAYER IP GMBH (DE) | 2017-10-18 | — | — | EP | disclosed |
| EP-2751106-B1 | SUBSTITUTED ANNELLATED PYRIMIDINE AND THE USE THEREOF | BAYER IP GMBH (DE) | 2017-10-18 | — | — | EP | disclosed |
| US-20150105374-A1 | Substituted annellated pyrimidines and use thereof | BAYER IP GMBH (DE) | 2015-04-16 | — | — | US | disclosed |
| US-20150105374-A1 | Substituted annellated pyrimidines and use thereof | BAYER IP GMBH (DE) | 2015-04-16 | — | — | US | disclosed |
| US-20150105374-A1 | Substituted annellated pyrimidines and use thereof | BAYER IP GMBH (DE) | 2015-04-16 | — | — | US | disclosed |
| EP-2802587-A2 | SUBSTITUTED, ANNULATED IMIDAZOLES AND PYRAZOLES, AND USE THEREOF | Bayer Intellectual Property GmbH (DE) | 2014-11-19 | — | — | EP | disclosed |
| US-8859569-B2 | Substituted annellated pyrimidines and use thereof | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-10-14 | — | — | US | disclosed |
| US-8859569-B2 | Substituted annellated pyrimidines and use thereof | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-10-14 | — | — | US | disclosed |
| EP-2751106-A1 | SUBSTITUTED ANNELLATED PYRIMIDINE AND THE USE THEREOF | Bayer Intellectual Property GmbH (DE) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013104598-A2 | SUBSTITUTED, ANNULATED IMIDAZOLES AND PYRAZOLES, AND USE THEREOF | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-07-18 | — | — | WO | disclosed |
| WO-2013030288-A1 | SUBSTITUTED ANNELLATED PYRIMIDINE AND THE USE THEREOF | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-03-07 | — | — | WO | disclosed |
| WO-2013030288-A1 | SUBSTITUTED ANNELLATED PYRIMIDINE AND THE USE THEREOF | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105374-A1 | Substituted annellated pyrimidines and use thereof | TYMS, TYMP, NUDT1 | GUCY1A1 2669/4885GUCY1B1 2119/4885KCNH2 3446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.