Sugi Predict

Sugi Predict / Compounds / SCHEMBL1474701

SCHEMBL1474701

SCHEMBL1474701

Cc1ccc(-c2cn3cc(-c4cccc(COc5ccc(C(F)(F)F)cc5)c4)ccc3n2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FFAR1 O14842 8/20 0.51
▸ THRB P10828 2/20 0.51
▸ POLB P06746 2/20 0.51
▸ MAPT P10636 2/20 0.51
▸ ALDH1A3 P47895 5/20 0.50
▸ SLC2A1 P11166 1/20 0.50
▸ PPARG P37231 1/20 0.49
▸ NR4A2 P43354 2/20 0.49
▸ KCNH2 Q12809 2/20 0.49
▸ CYP2C9 P11712 1/20 0.49
▸ KDM4E B2RXH2 2/20 0.47
▸ NPC1 O15118 2/20 0.47
▸ ALDH1A1 P00352 2/20 0.47
▸ HPGD P15428 2/20 0.47
▸ SMN1; SMN2 Q16637 2/20 0.47
▸ NFKB1 P19838 1/20 0.47
▸ RAB9A P51151 1/20 0.47
▸ GFER P55789 1/20 0.47
▸ NFKB2 Q00653 1/20 0.47
▸ RELA Q04206 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1474716 0.92 ALDH1A3 (0.59) FFAR1THRBPOLBMAPTALDH1A3
SCHEMBL1472663 0.87 NR4A2 (0.66) FFAR1ALDH1A3SLC2A1NR4A2KCNH2
SCHEMBL1472923 0.85 ALDH1A3 (0.58) FFAR1ALDH1A3SLC2A1NR4A2KCNH2
SCHEMBL1472990 0.83 MAOB (0.55) FFAR1POLBALDH1A3SLC2A1NR4A2
SCHEMBL24723564 0.83 AGXT (0.62) FFAR1
SCHEMBL1474910 0.81 ALDH1A1 (0.60) FFAR1POLBMAPTALDH1A3SLC2A1
SCHEMBL1472444 0.81 NR4A2 (0.73) FFAR1POLBMAPTALDH1A3SLC2A1
SCHEMBL1474690 0.78 RAB9A (0.54) POLBMAPTALDH1A3SLC2A1NR4A2
SCHEMBL1472658 0.76 NR4A2 (0.80) POLBALDH1A3SLC2A1NR4A2KCNH2
SCHEMBL16246668 0.74 ALDH1A3 (0.77) POLBMAPTALDH1A3SLC2A1NR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7915284-B2 2-aryl-6-phenylimidazo[1,2-a]pyridine derivatives, preparation thereof and therapeutic use thereof SANOFI-AVENTIS (FR) 2011-03-29 — — US claimed
EP-2069342-B1 2-ARYL-6-PHENYLIMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI AVENTIS (FR) 2010-05-12 — — EP claimed
US-20090253735-A1 2-ARYL-6-PHENYLIMIDAZO[1,2-a]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2009-10-08 — — US claimed
US-7915284-B2 2-aryl-6-phenylimidazo[1,2-a]pyridine derivatives, preparation thereof and therapeutic use thereof SANOFI-AVENTIS (FR) 2011-03-29 — — US disclosed
EP-2069342-B1 2-ARYL-6-PHENYLIMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI AVENTIS (FR) 2010-05-12 — — EP disclosed
US-20090253735-A1 2-ARYL-6-PHENYLIMIDAZO[1,2-a]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2009-10-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090253735-A1 2-ARYL-6-PHENYLIMIDAZO[1,2-a]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF NCOR1, NR4A2, NR4A3 FFAR1 231/4885THRB 377/4885POLB 3157/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.