Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.59 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.47 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6238132 | 0.85 | TAS1R3 (0.68) | TAS1R3TAS1R1POLBNPC1RAB9A | |
| SCHEMBL13723033 | 0.84 | FLT3 (0.59) | POLBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL12709572 | 0.82 | TAS1R3 (0.46) | TAS1R3TAS1R1THRBHDAC3HDAC4 | |
| SCHEMBL15219325 | 0.81 | KDM4E (0.58) | TAS1R3TAS1R1HPGDKDM4EALDH1A1 | |
| SCHEMBL3193244 | 0.80 | MEN1 (0.52) | TAS1R3TAS1R1POLBTHRBHDAC3 | |
| SCHEMBL10239431 | 0.79 | ALDH1A1 (0.68) | POLBNPC1RAB9AHPGDKDM4E | |
| SCHEMBL445586 | 0.76 | HPGD (0.57) | TAS1R3TAS1R1POLBHDAC3HDAC4 | |
| SCHEMBL8034219 | 0.75 | TAS1R3 (0.59) | TAS1R3TAS1R1NPC1RAB9AHPGD | |
| SCHEMBL8018089 | 0.75 | TAS1R3 (0.55) | TAS1R3TAS1R1NPC1RAB9AHPGD | |
| SCHEMBL702631 | 0.75 | PIM1 (0.64) | TAS1R3TAS1R1THRBHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389557-B2 | Triazole derivatives useful as Axl inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2013-03-05 | — | — | US | disclosed |