Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.55 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.55 |
| ▸ | MAOB | P27338 | 7/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA6 | P23280 | 1/20 | 0.54 |
| ▸ | CA5A | P35218 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.54 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29994212 | 1.00 | TAS1R3 (0.55) | TAS1R3TAS1R1MAOBCA12CA1 | |
| SCHEMBL11684788 | 0.85 | ALDH1A1 (0.69) | TAS1R3TAS1R1MAOBCA12CA1 | |
| SCHEMBL702631 | 0.85 | PIM1 (0.64) | TAS1R3TAS1R1MAOBCA12CA1 | |
| SCHEMBL4504897 | 0.84 | TAS1R3 (0.54) | TAS1R3TAS1R1MAOBCA12CA1 | |
| SCHEMBL8034219 | 0.82 | TAS1R3 (0.59) | TAS1R3TAS1R1MAOBCA12CA1 | |
| SCHEMBL6238132 | 0.82 | TAS1R3 (0.68) | TAS1R3TAS1R1MAOBCA12CA1 | |
| SCHEMBL23665730 | 0.81 | TAS1R3 (0.58) | TAS1R3TAS1R1MAOBCA12CA1 | |
| SCHEMBL1065473 | 0.81 | TAS1R3 (0.55) | TAS1R3TAS1R1MAOBCA12CA1 | |
| SCHEMBL16708233 | 0.80 | TAS1R3 (0.53) | TAS1R3TAS1R1MAOBCA12CA1 | |
| SCHEMBL10508628 | 0.79 | FLT3 (0.76) | MAOBCA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3131893-B1 | POLYCYCLIC HERG ACTIVATORS | NOVARTIS AG (CH) | 2020-02-12 | — | — | EP | disclosed |
| EP-3131893-B1 | POLYCYCLIC HERG ACTIVATORS | NOVARTIS AG (CH) | 2020-02-12 | — | — | EP | disclosed |
| CN-106604918-B | Polycyclic hERG activators | 诺华股份有限公司 | 2019-09-27 | — | — | CN | disclosed |
| CN-106604918-A | Polycyclic hERG activators | 诺华股份有限公司 | 2017-04-26 | — | — | CN | disclosed |
| EP-3131893-A1 | POLYCYCLIC HERG ACTIVATORS | Novartis AG (CH) | 2017-02-22 | — | — | EP | disclosed |
| US-20160108025-A1 | POLYCYCLIC HERG ACTIVATORS | NOVARTIS AG | 2016-04-21 | — | — | US | disclosed |
| US-20160108025-A1 | POLYCYCLIC HERG ACTIVATORS | NOVARTIS AG | 2016-04-21 | — | — | US | disclosed |
| US-20160108025-A1 | POLYCYCLIC HERG ACTIVATORS | NOVARTIS AG | 2016-04-21 | — | — | US | disclosed |
| US-9255093-B2 | Polycyclic HERG activators | NOVARTIS AG (CH) | 2016-02-09 | — | — | US | disclosed |
| US-9255093-B2 | Polycyclic HERG activators | NOVARTIS AG (CH) | 2016-02-09 | — | — | US | disclosed |
| EP-1497279-B1 | SUBSTITUTED INDOLES AND THEIR USE AS 5HT-REUPTAKE INHIBITORS AND AS 5HT LIGANDS | MERCK PATENT GMBH (DE) | 2011-03-09 | — | — | EP | disclosed |
| US-7888470-B2 | Chimeric T1R taste receptor polypeptides and nucleic acid sequences encoding and cell lines that express said chimeric T1R polypeptides | SENOMYX, INC. (US) | 2011-02-15 | — | — | US | disclosed |
| US-20090291963-A1 | SUBSTITUTED INDOLES | SCHADT OLIVER | 2009-11-26 | — | — | US | disclosed |
| US-20090291963-A1 | SUBSTITUTED INDOLES | SCHADT OLIVER | 2009-11-26 | — | — | US | disclosed |
| US-7572796-B2 | Substituted indoles | MERCK PATENT GMBH (DE) | 2009-08-11 | — | — | US | disclosed |
| US-7572796-B2 | Substituted indoles | MERCK PATENT GMBH (DE) | 2009-08-11 | — | — | US | disclosed |
| WO-2009094279-A1 | QUINOLIZIDINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2009-07-30 | — | — | WO | disclosed |
| US-20090054459-A1 | Substituted indoles | SCHADT OLIVER | 2009-02-26 | — | — | US | disclosed |
| US-20090054459-A1 | Substituted indoles | SCHADT OLIVER | 2009-02-26 | — | — | US | disclosed |
| US-20080085994-A1 | Chimeric binding protein for use in identifying compounds which respond to umami taste stimuli and sweet taste stimuli | SENOMYX, INC. | 2008-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054459-A1 | Substituted indoles | TPH2, TPH1, HTR1A | TAS1R3 3775/4885TAS1R1 3074/4885MAOB 52/4885 |
| US-20090291963-A1 | SUBSTITUTED INDOLES | TPH2, TPH1, HTR1A | TAS1R3 3802/4885TAS1R1 3125/4885MAOB 45/4885 |
| US-20160108025-A1 | POLYCYCLIC HERG ACTIVATORS | KCNH3, KCNH2, KCNJ11 | TAS1R3 2106/4885TAS1R1 2047/4885MAOB 2514/4885 |
| US-20080085994-A1 | Chimeric binding protein for use in identifying compounds which respond to umami taste stimuli and sweet taste stimuli | TAS1R3, TAS1R2, TAS2R30 | TAS1R3 1/4885TAS1R1 4/4885MAOB 4694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.