Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ACP3 | P15309 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18486592 | 0.82 | NPC1 (0.46) | NPC1RAB9AP2RX7KMT2AMEN1 | |
| SCHEMBL27628134 | 0.78 | PTGDR2 (0.41) | KMT2AMEN1ACP3PKMEPHX1 | |
| SCHEMBL777536 | 0.74 | DHODH (0.36) | NPC1RAB9AKMT2AMEN1LMNA | |
| SCHEMBL780831 | 0.74 | CA2 (0.46) | NPC1RAB9AKMT2AMEN1LMNA | |
| SCHEMBL10844112 | 0.74 | CA2 (0.46) | NPC1RAB9AKMT2AMEN1LMNA | |
| SCHEMBL778595 | 0.73 | ALDH1A1 (0.33) | RAB9AKMT2AMEN1ACP3 | |
| SCHEMBL8963295 | 0.72 | NPC1 (0.37) | NPC1RAB9AP2RX7KMT2AMEN1 | |
| SCHEMBL778321 | 0.72 | MEN1 (0.48) | NPC1RAB9AP2RX7KMT2AMEN1 | |
| SCHEMBL3888539 | 0.72 | SRC (0.48) | NPC1RAB9AP2RX7KMT2AMEN1 | |
| SCHEMBL24782558 | 0.72 | NPC1 (0.39) | NPC1RAB9AKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2275413-B1 | 2,4-di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | NOVARTIS AG (CH) | 2013-03-06 | — | — | EP | disclosed |