Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | LGMN | Q99538 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2935120 | 0.91 | MAPT (0.42) | ADRB1BRD4CDK1MAPTALDH1A1 | |
| SCHEMBL2939391 | 0.82 | MAPT (0.41) | CDK1MAPTALDH1A1ALOX15MAPK1 | |
| SCHEMBL1912064 | 0.81 | SUV39H2 (0.47) | ADRB1BRD4SUV39H2MAPTALDH1A1 | |
| SCHEMBL24670695 | 0.80 | ADRB1 (0.41) | ADRB1BRD4MAP2K7RORCSUV39H2 | |
| SCHEMBL30066216 | 0.80 | ADRB1 (0.41) | ADRB1BRD4MAP2K7RORCSUV39H2 | |
| SCHEMBL24206625 | 0.80 | GAA (0.57) | ADRB1BRD4CDK1MAP2K7RORC | |
| SCHEMBL2940683 | 0.80 | MAPT (0.46) | MAPTALDH1A1ALOX15MAPK1GFER | |
| SCHEMBL14747886 | 0.79 | LIPG (0.38) | ADRB1CDK1MAPTALDH1A1MAPK1 | |
| SCHEMBL10642901 | 0.78 | ADRB1 (0.53) | ADRB1BRD4RORCMAPTALDH1A1 | |
| SCHEMBL1599743 | 0.78 | ALDH1A1 (0.49) | ADRB1MAPTALDH1A1ALOX15MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2275413-B1 | 2,4-di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | NOVARTIS AG (CH) | 2013-03-06 | — | — | EP | disclosed |