Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14748256 | 0.79 | NPSR1 (0.50) | EPHX1HPGDKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL29889521 | 0.72 | ALDH1A1 (0.40) | ALDH1A1LMNADRD2HTR2ADRD3 | |
| SCHEMBL1698397 | 0.71 | EPHX1 (0.76) | EPHX1HPGDKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3075216 | 0.70 | EPHX1 (0.68) | EPHX1HPGDKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL29889462 | 0.69 | HTT (0.42) | KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL394283 | 0.69 | HSD11B1 (0.58) | EPHX1HPGDKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL10304524 | 0.69 | SIGMAR1 (0.67) | EPHX1HPGDKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL10587847 | 0.68 | ALDH1A1 (0.83) | EPHX1HPGDKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL879434 | 0.67 | EPHX1 (0.63) | EPHX1HPGDKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2089150 | 0.67 | EPHX1 (0.63) | EPHX1HPGDKMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334657-B1 | PIPERAZINE D3 AND 5-HT2A RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2013-03-06 | — | — | EP | disclosed |