Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | DAO | P14920 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 2/20 | 0.43 |
| ▸ | RORB | Q92753 | 2/20 | 0.43 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1797326 | 0.84 | KDM4E (0.55) | KMT2ADAOKDM4EMEN1ALDH1A1 | |
| SCHEMBL10109878 | 0.83 | MAPK14 (0.46) | KMT2AKDM4EALDH1A1NPC1POLB | |
| SCHEMBL424378 | 0.82 | RAB9A (0.43) | KMT2ADAOMEN1NPC1POLB | |
| SCHEMBL13285423 | 0.82 | POLB (0.43) | KMT2AMEN1ALDH1A1NPC1POLB | |
| SCHEMBL14748324 | 0.79 | HPGD (0.52) | KMT2ADAOKDM4EMEN1ALDH1A1 | |
| SCHEMBL6255667 | 0.74 | ALDH1A1 (0.52) | KMT2ADAOKDM4EMEN1ALDH1A1 | |
| SCHEMBL424173 | 0.73 | PTGDR2 (0.49) | MAPTPIN1 | |
| SCHEMBL5924981 | 0.73 | DAO (0.50) | KMT2ADAOKDM4EMEN1ALDH1A1 | |
| SCHEMBL3754699 | 0.73 | HPGDS (0.69) | KMT2AMEN1ALDH1A1POLBRAB9A | |
| SCHEMBL34469599 | 0.73 | MAPK14 (0.58) | KMT2ADAOKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376482-B1 | SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF | AICURIS GMBH & CO KG (DE) | 2013-03-06 | — | — | EP | disclosed |