Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14475724 | 0.90 | EGFR (0.62) | CSNK2A1KDM4ETHRBKMT2AMAPT | |
| SCHEMBL14749157 | 0.85 | KMT2A (0.57) | CSNK2A1KDM4ETHRBKMT2AMAPT | |
| SCHEMBL15931501 | 0.82 | MAPT (0.57) | CSNK2A1KDM4ETHRBKMT2AMAPT | |
| SCHEMBL14749107 | 0.79 | MEN1 (0.64) | KDM4EKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL14476952 | 0.76 | KMT2A (0.67) | CSNK2A1KDM4ETHRBKMT2AMAPT | |
| SCHEMBL13833830 | 0.76 | MAPT (0.59) | CSNK2A1KDM4ETHRBKMT2AMAPT | |
| SCHEMBL8636910 | 0.71 | CSNK2A1 (0.67) | CSNK2A1KDM4ETHRBKMT2AMAPT | |
| SCHEMBL8636906 | 0.71 | CSNK2A1 (0.67) | CSNK2A1KDM4ETHRBKMT2AMAPT | |
| SCHEMBL8995999 | 0.69 | EGFR (0.64) | THRBKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL14475725 | 0.69 | EGFR (0.72) | KDM4EKMT2AMAPTMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180100166-A1 | Compositions and Methods for Enhancing Bioenergetic Status in Female Germ Cells | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2018-04-12 | — | — | US | disclosed |
| US-20180085383-A1 | SMALL MOLECULE CD38 INHIBITORS AND METHODS OF USING SAME | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2018-03-29 | — | — | US | disclosed |
| US-9845482-B2 | Compositions and methods for enhancing bioenergetic status in female germ cells | THE GENERAL HOSPITAL CORPORATION (US) | 2017-12-19 | — | — | US | disclosed |
| US-20160024527-A1 | Compositions and Methods for Enhancing Bioenergetic Status in Female Germ Cells | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2016-01-28 | — | — | US | disclosed |
| US-20140221319-A1 | Small Molecule CD38 Inhibitors and Methods of Using Same | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2014-08-07 | — | — | US | disclosed |
| US-20130059384-A1 | COMPOSITIONS AND METHODS FOR ENHANCING BIOENERGETIC STATUS IN FEMALE GERM CELLS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221319-A1 | Small Molecule CD38 Inhibitors and Methods of Using Same | CD38, CD22, CD2 | CSNK2A1 1966/4885KDM4E 1900/4885THRB 4582/4885 |
| US-20180100166-A1 | Compositions and Methods for Enhancing Bioenergetic Status in Female Germ Cells | PCK2, GSR, TFAM | CSNK2A1 2586/4885KDM4E 2420/4885THRB 3851/4885 |
| US-20130059384-A1 | COMPOSITIONS AND METHODS FOR ENHANCING BIOENERGETIC STATUS IN FEMALE GERM CELLS | PCK2, GSR, TFAM | CSNK2A1 2586/4885KDM4E 2420/4885THRB 3851/4885 |
| US-20160024527-A1 | Compositions and Methods for Enhancing Bioenergetic Status in Female Germ Cells | PCK2, GSR, TFAM | CSNK2A1 2586/4885KDM4E 2420/4885THRB 3851/4885 |
| US-20180085383-A1 | SMALL MOLECULE CD38 INHIBITORS AND METHODS OF USING SAME | CD38, BCL6B, DNASE1L3 | CSNK2A1 2014/4885KDM4E 1524/4885THRB 4378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.