SCHEMBL14749828

SCHEMBL14749828

C=C(C(=O)OC)C(C)C(=O)OC

nearest known ligand 0.44

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.39
CA14 Q9ULX7 2/20 0.37
TSHR P16473 2/20 0.35
CA12 O43570 1/20 0.34
KMT2A Q03164 2/20 0.30
MEN1 O00255 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4710209 0.81 ALDH1A1 (0.44) ALDH1A1SMN1; SMN2TSHR
Ammonia Solution, Strong SCHEMBL28843678 0.80 ALDH1A1 (0.48) ALDH1A1SMN1; SMN2CA14TSHR
SCHEMBL29001043 0.79 ALDH1A1 (0.42) ALDH1A1CA14TSHR
SCHEMBL11318092 0.77 ALDH1A1 (0.41) ALDH1A1
SCHEMBL3909058 0.77
SCHEMBL10761672 0.76 ALDH1A1 (0.44) ALDH1A1SMN1; SMN2CA14TSHRCA12
SCHEMBL275280 0.76 SMN1; SMN2 (0.52) ALDH1A1SMN1; SMN2CA14TSHRCA12
SCHEMBL5143818 0.75 SMN1; SMN2 (0.42) ALDH1A1SMN1; SMN2CA14TSHRCA12
SCHEMBL599284 0.75
SCHEMBL3859257 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4656638-A2 PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF Japan Tobacco Inc. (JP) 2025-12-03 EP disclosed
US-20230348438-A1 PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF JAPAN TOBACCO INC. (JP) 2023-11-02 US disclosed
US-20230348438-A1 PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF JAPAN TOBACCO INC. (JP) 2023-11-02 US disclosed
US-20230348438-A1 PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF JAPAN TOBACCO INC. (JP) 2023-11-02 US disclosed
US-20230210831-A1 CHRONIC KIDNEY DISEASE TREATMENT OR PREVENTION METHOD JAPAN TOBACCO INC. (JP) 2023-07-06 US disclosed
CN-115697327-A 5-oxo-pyrrolidine-3-carboxamides as NAV1.8 inhibitors 默沙东有限责任公司 2023-02-03 CN disclosed
US-20200317644-A1 PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF JAPAN TOBACCO INC (JP) 2020-10-08 US disclosed
US-20200317644-A1 PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF JAPAN TOBACCO INC (JP) 2020-10-08 US disclosed
EP-3524599-A1 PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF Japan Tobacco Inc. (JP) 2019-08-14 EP disclosed
US-20180346449-A1 PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF JAPAN TOBACCO INC (JP) 2018-12-06 US disclosed
CN-103917535-B Pyrazole compounds and pharmaceutical use thereof JAPAN TOBACCO INC 2015-06-24 CN disclosed
EP-2784074-A1 PYRAZOLE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES Japan Tobacco, Inc. (JP) 2014-10-01 EP disclosed
US-8846746-B2 Pyrazole compound and pharmaceutical use thereof JAPAN TOBACCO INC. (JP) 2014-09-30 US disclosed
US-8846746-B2 Pyrazole compound and pharmaceutical use thereof JAPAN TOBACCO INC. (JP) 2014-09-30 US disclosed
US-8846746-B2 Pyrazole compound and pharmaceutical use thereof JAPAN TOBACCO INC. (JP) 2014-09-30 US disclosed
CN-103917535-A Pyrazole compounds and pharmaceutical use thereof JAPAN TOBACCO INC 2014-07-09 CN disclosed
US-20130085132-A1 PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF JAPAN TOBACCO INC. (JP) 2013-04-04 US disclosed
US-20130085132-A1 PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF JAPAN TOBACCO INC. (JP) 2013-04-04 US disclosed
US-20130085132-A1 PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF JAPAN TOBACCO INC. (JP) 2013-04-04 US disclosed
WO-2013031922-A1 PYRAZOLE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES 日本たばこ産業株式会社 (JP) 2013-03-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180346449-A1 PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF CYP2C19, CYP3A7, CYP3A5 ALDH1A1 1200/4885SMN1; SMN2 4079/4885CA14 1801/4885
US-20230348438-A1 PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF CYP2C19, CYP3A7, CYP3A5 ALDH1A1 1200/4885SMN1; SMN2 4079/4885CA14 1801/4885
US-20130085132-A1 PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF SLC5A1, SLC5A2, SLC34A1 ALDH1A1 676/4885SMN1; SMN2 4518/4885CA14 2578/4885
US-20230210831-A1 CHRONIC KIDNEY DISEASE TREATMENT OR PREVENTION METHOD SLC5A1, SLC5A2, REN ALDH1A1 804/4885SMN1; SMN2 4173/4885CA14 1301/4885
US-20200317644-A1 PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF CYP2C19, CYP3A7, CYP3A5 ALDH1A1 1200/4885SMN1; SMN2 4079/4885CA14 1801/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.