Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 8/20 | 0.56 |
| ▸ | BRD2 | P25440 | 8/20 | 0.56 |
| ▸ | BRD3 | Q15059 | 7/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 6/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 6/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 6/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26071914 | 0.88 | CYP11B1 (0.47) | BRD4BRD2BRD3TSHRALDH1A1 | |
| SCHEMBL18871831 | 0.87 | PDK1 (0.49) | BRD4BRD2BRD3TSHRALDH1A1 | |
| SCHEMBL26071793 | 0.86 | PDK1 (0.54) | BRD4BRD2BRD3TSHRALDH1A1 | |
| SCHEMBL14756207 | 0.86 | PDK1 (0.54) | BRD4BRD2BRD3TSHRALDH1A1 | |
| SCHEMBL18871979 | 0.86 | PDK1 (0.51) | BRD4BRD2BRD3TSHRPDK1 | |
| SCHEMBL14756232 | 0.84 | PDK1 (0.47) | BRD4BRD2BRD3TSHRALDH1A1 | |
| SCHEMBL14756761 | 0.83 | PDK1 (0.45) | BRD4BRD2BRD3TSHRALDH1A1 | |
| SCHEMBL18871765 | 0.83 | PDK1 (0.50) | TSHRALDH1A1HTTLMNAPDK1 | |
| SCHEMBL30366353 | 0.83 | PDK1 (0.48) | TSHRALDH1A1HTTLMNAPDK1 | |
| SCHEMBL26072484 | 0.83 | PDK1 (0.48) | TSHRALDH1A1HTTLMNAPDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3168213-B1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2018-08-01 | — | — | EP | disclosed |
| EP-3168213-A1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | Glaxosmithkline LLC (US) | 2017-05-17 | — | — | EP | disclosed |
| WO-2013033270-A2 | BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME | COFERON, INC. (US) | 2013-03-07 | — | — | WO | disclosed |
| WO-2013033269-A1 | BIOORTHOGONAL MONOMERS CAPABLE OF DIMERIZING AND TARGETING BROMODOMAINS AND METHODS OF USING SAME | COFERON, INC. (US) | 2013-03-07 | — | — | WO | disclosed |
| WO-2013033268-A2 | BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME | COFERON, INC. (US) | 2013-03-07 | — | — | WO | disclosed |