Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 9/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 9/20 | 0.47 |
| ▸ | PDK3 | Q15120 | 9/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 9/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 5/20 | 0.44 |
| ▸ | BRD2 | P25440 | 5/20 | 0.44 |
| ▸ | BRD3 | Q15059 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TAF1 | P21675 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26071793 | 0.90 | PDK1 (0.54) | PDK1PDK2PDK3PDK4MAPK1 | |
| SCHEMBL14756207 | 0.90 | PDK1 (0.54) | PDK1PDK2PDK3PDK4MAPK1 | |
| SCHEMBL26071914 | 0.89 | CYP11B1 (0.47) | PDK1PDK2PDK3PDK4MAPK1 | |
| SCHEMBL14756175 | 0.84 | BRD4 (0.56) | PDK1PDK2PDK3PDK4BRD4 | |
| SCHEMBL14756761 | 0.84 | PDK1 (0.45) | PDK1PDK2PDK3PDK4MAPK1 | |
| SCHEMBL30366353 | 0.84 | PDK1 (0.48) | PDK1PDK2PDK3PDK4MAPK1 | |
| SCHEMBL26072484 | 0.84 | PDK1 (0.48) | PDK1PDK2PDK3PDK4MAPK1 | |
| SCHEMBL26071772 | 0.83 | ALDH1A1 (0.45) | PDK1PDK2PDK3PDK4MAPK1 | |
| SCHEMBL26071929 | 0.83 | ALDH1A1 (0.45) | PDK1PDK2PDK3PDK4MAPK1 | |
| SCHEMBL18871998 | 0.82 | PDK1 (0.58) | PDK1PDK2PDK3PDK4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015081280-A1 | BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION | COFERON, INC. (US) | 2015-06-04 | — | — | WO | disclosed |
| WO-2015081284-A1 | BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME | COFERON, INC. (US) | 2015-06-04 | — | — | WO | disclosed |
| WO-2013033268-A2 | BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME | COFERON, INC. (US) | 2013-03-07 | — | — | WO | disclosed |
| WO-2013033270-A2 | BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME | COFERON, INC. (US) | 2013-03-07 | — | — | WO | disclosed |