Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14756313 | 0.89 | HRH3 (0.39) | HRH3TAAR1LMNAALOX15ALDH1A1 | |
| SCHEMBL14756195 | 0.81 | BACE1 (0.46) | HRH3TAAR1LMNAALOX15ALDH1A1 | |
| SCHEMBL14756332 | 0.78 | PLAU (0.36) | HRH3LMNACHRM2PDE10AGRM1 | |
| SCHEMBL14037347 | 0.78 | TERT (0.36) | LMNAALOX15PDE10AGRM1CYP1A2 | |
| SCHEMBL15985138 | 0.77 | HRH3 (0.35) | HRH3TAAR1LMNAALOX15ALDH1A1 | |
| SCHEMBL9688391 | 0.76 | PDE10A (0.50) | HRH3TAAR1LMNAALOX15ALDH1A1 | |
| SCHEMBL15985340 | 0.75 | MAPT (0.46) | HRH3TAAR1LMNAALOX15ALDH1A1 | |
| SCHEMBL14216636 | 0.74 | KCNH2 (0.50) | ALDH1A1NOS1PDE10AMAPT | |
| SCHEMBL14756197 | 0.72 | TAAR1 (0.46) | HRH3TAAR1LMNAALOX15ALDH1A1 | |
| SCHEMBL14756314 | 0.71 | MAPT (0.45) | TAAR1LMNAALOX15ALDH1A1NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013033268-A2 | BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME | COFERON, INC. (US) | 2013-03-07 | — | — | WO | disclosed |