Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | UBE2N | P61088 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14756305 | 0.87 | HRH1 (0.33) | LMNAHRH1MEN1F2CHRM2 | |
| SCHEMBL14756191 | 0.79 | BACE1 (0.55) | PLAUKDM4EMEN1KMT2ABACE1 | |
| SCHEMBL14352128 | 0.79 | BACE1 (0.55) | PLAUIDO1PDE10ABACE1MPO | |
| SCHEMBL14756331 | 0.78 | HRH3 (0.38) | LMNACHRM2HRH3PDE10AGRM1 | |
| SCHEMBL14216636 | 0.78 | KCNH2 (0.50) | PLAUKCNH2CYSLTR2CYSLTR1PDE10A | |
| SCHEMBL14037347 | 0.78 | TERT (0.36) | LMNAKDM4EPOLBCASP6MEN1 | |
| SCHEMBL10734459 | 0.76 | HTR7 (0.41) | PLAULMNAKDM4EPOLBCASP6 | |
| SCHEMBL14352239 | 0.75 | NCF1 (0.58) | LMNAKDM4EPOLBMEN1MAOA | |
| SCHEMBL15981505 | 0.73 | KDM4E (0.34) | PLAULMNAKDM4EPOLBCASP6 | |
| SCHEMBL2305245 | 0.73 | PDE10A (0.50) | HRH1MEN1KMT2ACYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013033268-A2 | BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME | COFERON, INC. (US) | 2013-03-07 | — | — | WO | disclosed |