Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.75 |
| ▸ | USP2 | O75604 | 3/20 | 0.72 |
| ▸ | ATM | Q13315 | 2/20 | 0.72 |
| ▸ | CFTR | P13569 | 1/20 | 0.72 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.72 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16024743 | 0.87 | ABCB1 (0.79) | ABCB1USP2ATMCFTRPAX8 | |
| SCHEMBL10167878 | 0.87 | ABCB1 (0.79) | ABCB1USP2ATMCFTRPAX8 | |
| SCHEMBL268381 | 0.86 | ABCB1 (1.00) | ABCB1USP2ATMCFTRPAX8 | |
| SCHEMBL12285238 | 0.85 | ABCB1 (0.76) | ABCB1USP2ATMCFTRPAX8 | |
| Hydrochloric Acid SCHEMBL3808879 | 0.85 | USP2 (0.98) | ABCB1USP2ATMCFTRPAX8 | |
| Hydrochloric Acid SCHEMBL29363314 | 0.85 | USP2 (0.98) | ABCB1USP2ATMCFTRPAX8 | |
| Hydrochloric Acid SCHEMBL18816029 | 0.85 | USP2 (0.98) | ABCB1USP2ATMCFTRPAX8 | |
| SCHEMBL20216437 | 0.85 | ABCB1 (0.70) | ABCB1USP2ATMCFTRPAX8 | |
| SCHEMBL13881098 | 0.83 | ABCB1 (0.74) | ABCB1USP2ATMCFTRPAX8 | |
| SCHEMBL15006531 | 0.83 | ABCB1 (0.74) | ABCB1USP2ATMCFTRPAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210379190-A1 | FAP-ACTIVATED PROTEASOME INHIBITORS FOR TREATING SOLID TUMORS | TRUSTEES OF TUFTS COLLEGE | 2021-12-09 | — | — | US | disclosed |
| US-11065339-B2 | FAP-activated proteasome inhibitors for treating solid tumors | TRUSTEES OF TUFTS COLLEGE (US) | 2021-07-20 | — | — | US | disclosed |
| US-20200323994-A1 | FAP-ACTIVATED PROTEASOME INHIBITORS FOR TREATING SOLID TUMORS | TRUSTEES OF TUFTS COLLEGE | 2020-10-15 | — | — | US | disclosed |
| US-20190054181-A1 | FAP-ACTIVATED PROTEASOME INHIBITORS FOR TREATING SOLID TUMORS | TRUSTEES OF TUFTS COLLEGE | 2019-02-21 | — | — | US | disclosed |
| US-9956297-B2 | FAP-activated proteasome inhibitors for treating solid tumors | TRUSTEES OF TUFTS COLLEGE (US) | 2018-05-01 | — | — | US | disclosed |
| WO-2013033396-A2 | FAP-ACTIVATED PROTEASOME INHIBITORS FOR TREATING SOLID TUMORS | TRUSTEES OF TUFTS COLLEGE (US) | 2013-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210379190-A1 | FAP-ACTIVATED PROTEASOME INHIBITORS FOR TREATING SOLID TUMORS | FAP, PSMA1, PSMA6 | ABCB1 473/4885USP2 97/4885ATM 2271/4885 |
| US-11065339-B2 | FAP-activated proteasome inhibitors for treating solid tumors | FAP, PSMA1, PSMA6 | ABCB1 473/4885USP2 97/4885ATM 2271/4885 |
| US-20200323994-A1 | FAP-ACTIVATED PROTEASOME INHIBITORS FOR TREATING SOLID TUMORS | FAP, PSMA1, PSMA6 | ABCB1 473/4885USP2 97/4885ATM 2271/4885 |
| US-20190054181-A1 | FAP-ACTIVATED PROTEASOME INHIBITORS FOR TREATING SOLID TUMORS | FAP, PSMA1, PSMA6 | ABCB1 473/4885USP2 97/4885ATM 2271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.